دورية أكاديمية
The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor
| العنوان: | The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor |
|---|---|
| المؤلفون: | Hochstoeger, T., Al Said, T., Maestre, D., Walter, F., Vilceanu, A., Pedron, M., Cushion, T., Snider, W., Nimpf, S., Nordmann, G., Landler, L., Edelman, N., Kruppa, L., Duernberger, G., Mechtler, K., Schuechner, S., Ogris, E., Malkemper, E., Weber, S., Schleicher, E., Keays, D. |
| المصدر: | Science Advances |
| سنة النشر: | 2020 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the retina but enriched at synapses in the outer plexiform layer in a repetitive manner. A proteomic survey for retinal-specific clCRY4 interactors identified molecules that are involved in receptor signaling, including glutamate receptor-interacting protein 2, which colocalizes with clCRY4. Our data support a model whereby clCRY4 acts as an ultraviolet-blue photoreceptor and/or a light-dependent magnetosensor by modulating glutamatergic synapses between horizontal cells and cones. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32851187; http://hdl.handle.net/21.11116/0000-0006-F847-3Test; http://hdl.handle.net/21.11116/0000-0006-F849-1Test |
| الإتاحة: | https://doi.org/10.1126/sciadv.abb9110Test http://hdl.handle.net/21.11116/0000-0006-F847-3Test http://hdl.handle.net/21.11116/0000-0006-F849-1Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9E3ABFA7 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |