دورية أكاديمية
Narcolepsy type 1 features across the life span: Age impact on clinical and polysomnographic phenotype
| العنوان: | Narcolepsy type 1 features across the life span: Age impact on clinical and polysomnographic phenotype |
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| المؤلفون: | Lividini A., Pizza F., Filardi M., Vandi S., Ingravallo F., Antelmi E., Bruni O., Cosentino F. I. I., Ferri R., Guarnieri B., Marelli S., Ferini-Strambi L., Romigi A., Bonanni E., Maestri M., Terzaghi M., Manni R., Plazzi G. |
| المساهمون: | Lividini, A., Pizza, F., Filardi, M., Vandi, S., Ingravallo, F., Antelmi, E., Bruni, O., Cosentino, F. I. I., Ferri, R., Guarnieri, B., Marelli, S., Ferini-Strambi, L., Romigi, A., Bonanni, E., Maestri, M., Terzaghi, M., Manni, R., Plazzi, G. |
| بيانات النشر: | American Academy of Sleep Medicine |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cataplexy, Emotional triggers, Narcolepsy type 1, Nocturnal sleep, Sleepiness |
| الوصف: | Study Objectives: Narcolepsy type 1 (NT1) is a chronic neurological disorder typically arising during adolescence and young adulthood. Recent studies demonstrated that NT1 presents with age-specific features, especially in children. With this study we aimed to describe and to compare the clinical pictures of NT1 in different age groups. Methods: In this cross-sectional, multicenter study, 106 untreated patients with NT1 enrolled at the time of diagnosis underwent clinical evaluation, a semistructured interview (including the Epworth Sleepiness Scale), nocturnal video-polysomnography, and the Multiple Sleep Latency Test. Patients were enrolled in order to establish 5 age-balanced groups (childhood, adolescence, adulthood, middle age, and senior). Results: The Epworth Sleepiness Scale score showed a significant increase with age, while self-reported diurnal total sleep time was lower in older and young adults, with the latter also complaining of automatic behaviors in more than 90% of patients. Children reported the cataplexy attacks to be more frequent (> 1/d in 95% of patients). "Recalling an emotional event,""meeting someone unexpectedly,""stress,"and "anger"were more frequently reported in adult and older adult patients as possible triggers of cataplexy. Neurophysiological data showed a higher number of sleep-onset rapid eye movement periods on the Multiple Sleep Latency Test in adolescent compared to senior patients and an age-progressive decline in sleep efficiency. Conclusions: Daytime sleepiness, cataplexy features and triggers, and nocturnal sleep structure showed age-related difference in patients with NT1; this variability may contribute to diagnostic delay and misdiagnosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33666167; info:eu-repo/semantics/altIdentifier/wos/WOS:000735659300006; volume:17; issue:7; firstpage:1363; lastpage:1370; numberofpages:8; journal:JOURNAL OF CLINICAL SLEEP MEDICINE; https://hdl.handle.net/20.500.11768/136536Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85112490211 |
| DOI: | 10.5664/jcsm.9198 |
| الإتاحة: | https://doi.org/20.500.11768/136536Test https://doi.org/10.5664/jcsm.9198Test https://hdl.handle.net/20.500.11768/136536Test |
| رقم الانضمام: | edsbas.9DE40D20 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5664/jcsm.9198 |
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