دورية أكاديمية
Phase II study of eribulin in combination with gemcitabine for the treatment of patients with locally advanced or metastatic triple negative breast cancer (ERIGE trial). Clinical and pharmacogenetic results on behalf of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC)
| العنوان: | Phase II study of eribulin in combination with gemcitabine for the treatment of patients with locally advanced or metastatic triple negative breast cancer (ERIGE trial). Clinical and pharmacogenetic results on behalf of the Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) |
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| المؤلفون: | Pellegrino B., Cavanna L., Boggiani D., Zamagni C., Frassoldati A., Schirone A., Caldara A., Rocca A., Gori S., Piacentini F., Berardi R., Brandes A. A., Foglietta J., Villa F., Todeschini R., Tognetto M., Naldi N., Bortesi B., Montemurro F., Ardizzoni A., Boni L., Musolino A. |
| المساهمون: | Pellegrino B., Cavanna L., Boggiani D., Zamagni C., Frassoldati A., Schirone A., Caldara A., Rocca A., Gori S., Piacentini F., Berardi R., Brandes A.A., Foglietta J., Villa F., Todeschini R., Tognetto M., Naldi N., Bortesi B., Montemurro F., Ardizzoni A., Boni L., Musolino A. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | breast cancer, eribulin, gemcitabine, metastatic, pharmacogenetic, TNBC, Antineoplastic Combined Chemotherapy Protocol, Deoxycytidine, Female, Furan, Human, Ketone, Microfilament Protein, Prospective Studie, Triple Negative Breast Neoplasms |
| الوصف: | Background: The combination of a microtubule inhibitor (eribulin) with a nucleoside analog (gemcitabine) may synergistically induce tumor cell death, particularly in triple negative breast cancer (TNBC) characterized by high cell proliferation, aggressive behavior, and chemo-resistance. Patients and methods: This is an open-label, multicenter phase II study evaluating the combination of eribulin (0.88 mg/m2) plus gemcitabine (1000 mg/m2) on days 1 and 8 of a 21-day cycle as either first- or second-line treatment of locally advanced or metastatic TNBC. The primary endpoint was the objective response for evaluable patients. A prospective, molecular correlative study was carried out to assess the role of germinal BRCA pathogenic variants and single nucleotide polymorphisms (SNPs) in predicting efficacy and toxicity of the combination regimen. Results: From July 2013 to September 2016, 83 evaluable patients were enrolled. They received a median number of six cycles of treatment. An overall response rate (ORR) of 37.3% (31 patients) was observed, with a complete response rate of 2.4% and a partial response rate of 34.9%; the clinical benefit rate was 48.8%. With a median follow-up of 28.8 months, the median response duration was 6.6 months, the median progression-free survival (PFS) was 5.1 months, and the median overall survival (OS) was 14.5 months. The most common grade 3-4 adverse events were aminotransferase elevation (in 25% of the patients) and neutropenia (in 23.8%). Women with BRCA1/2 pathogenic variants were associated with worse ORR, PFS, and OS than BRCA1/2 wild-type carriers. CYP3A4 and FGD4 SNPs were associated with increased risk of liver toxicity. Three different SNPs in CDA∗2, RRM1, and CYP2C8 genes were significantly associated with poorer OS. Conclusions: The combination of eribulin and gemcitabine showed promising activity and a moderate toxicity profile in metastatic TNBC. BRCA status and pharmacogenetics tests may help identify patients with high probability of response with negligible toxicity. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33399082; info:eu-repo/semantics/altIdentifier/wos/WOS:000631402900017; volume:6; issue:1; firstpage:1; lastpage:8; numberofpages:8; journal:ESMO OPEN; http://hdl.handle.net/11585/851662Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100641127; https://doi.org/10.1016/j.esmoop.2020.100019Test |
| DOI: | 10.1016/j.esmoop.2020.100019 |
| الإتاحة: | https://doi.org/10.1016/j.esmoop.2020.100019Test http://hdl.handle.net/11585/851662Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9DD17CCC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.esmoop.2020.100019 |
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