التفاصيل البيبلوغرافية
| العنوان: |
Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease |
| المؤلفون: |
Chatterjee, P., Pedrini, S., Ashton, N.J., Tegg, M., Goozee, K., Singh, A.K., Karikari, T.K., Simrén, J., Vanmechelen, E., Armstrong, N.J., Hone, E., Asih, P.R., Taddei, K., Doré, V., Villemagne, V.L., Sohrabi, H.R., Zetterberg, H., Masters, C.L., Blennow, K., Martins, R.N. |
| المصدر: |
Chatterjee, P., Pedrini, S., Ashton, N.J., Tegg, M., Goozee, K., Singh, A.K., Karikari, T.K., Simrén, J., Vanmechelen, E., Armstrong, N.J. orcid:0000-0002-4477-293X , Hone, E., Asih, P.R., Taddei, K., Doré, V., Villemagne, V.L., Sohrabi, H.R. orcid:0000-0001-8017-8682 , Zetterberg, H., Masters, C.L., Blennow, K. and Martins, R.N. (2021) Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease. Alzheimer's & Dementia . Early View. |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Murdoch University: Murdoch Research Repository |
| الوصف: |
Introduction This study involved a parallel comparison of the diagnostic and longitudinal monitoring potential of plasma glial fibrillary acidic protein (GFAP), total tau (t-tau), phosphorylated tau (p-tau181 and p-tau231), and neurofilament light (NFL) in preclinical Alzheimer's disease (AD). Methods Plasma proteins were measured using Simoa assays in cognitively unimpaired older adults (CU), with either absence (Aβ−) or presence (Aβ+) of brain amyloidosis. Results Plasma GFAP, t-tau, p-tau181, and p-tau231 concentrations were higher in Aβ+ CU compared with Aβ− CU cross-sectionally. GFAP had the highest effect size and area under the curve (AUC) in differentiating between Aβ+ and Aβ− CU; however, no statistically significant differences were observed between the AUCs of GFAP, p-tau181, and p-tau231, but all were significantly higher than the AUC of NFL, and the AUC of GFAP was higher than the AUC of t-tau. The combination of a base model (BM), comprising the AD risk factors, age, sex, and apolipoprotein E gene (APOE) ε4 status with GFAP was observed to have a higher AUC (>90%) compared with the combination of BM with any of the other proteins investigated in the current study. Longitudinal analyses showed increased GFAP and p-tau181 in Aβ+ CU and increased NFL in Aβ− CU, over a 12-month duration. GFAP, p-tau181, p-tau231, and NFL showed significant correlations with cognition, whereas no significant correlations were observed with hippocampal volume. Discussion These findings highlight the diagnostic and longitudinal monitoring potential of GFAP and p-tau for preclinical AD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://researchrepository.murdoch.edu.au/id/eprint/62169Test/; full_text_status:none |
| الإتاحة: |
https://researchrepository.murdoch.edu.au/id/eprint/62169Test/ |
| حقوق: |
© 2021 the Alzheimer's Association |
| رقم الانضمام: |
edsbas.9DC6E12A |
| قاعدة البيانات: |
BASE |
