دورية أكاديمية
Elovanoids Downregulate SARS-CoV-2 Cell-Entry, Canonical Mediators and Enhance Protective Signaling in Human Alveolar Cells
| العنوان: | Elovanoids Downregulate SARS-CoV-2 Cell-Entry, Canonical Mediators and Enhance Protective Signaling in Human Alveolar Cells |
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| المؤلفون: | Calandria, Jorgelina M., Bhattacharjee, Surjyadipta, Maness, Nicholas J., Kautzmann, Marie Audrey I., Asatryan, Aram, Gordon, William C., Do, Khanh V., Jun, Bokkyoo, Mukherjee, Pranab K., Petasis, Nicos A., Bazan, Nicolas G. |
| المصدر: | School of Medicine Faculty Publications |
| بيانات النشر: | LSU Health Digital Scholar |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Medical Specialties, Medicine and Health Sciences, Ophthalmology |
| الوصف: | The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture. We uncovered that very-long-chain polyunsaturated fatty acid precursors (VLC-PUFA, n-3) activate ELV biosynthesis in lung cells. Both ELVs and their precursors reduce the binding to RBD. ELVs downregulate angiotensin-converting enzyme 2 (ACE2) and enhance the expression of a set of protective proteins hindering cell surface virus binding and upregulating defensive proteins against lung damage. In addition, ELVs and their precursors decreased the signal of spike (S) protein found in SARS-CoV-2 infected cells, suggesting that the lipids curb viral infection. These findings open avenues for potential preventive and disease-modifiable therapeutic approaches for COVID-19. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://digitalscholar.lsuhsc.edu/som_facpubs/193Test; https://digitalscholar.lsuhsc.edu/context/som_facpubs/article/1192/viewcontent/CalandriaM_ElovanoidsDownregulateSars_20210610.pdfTest |
| DOI: | 10.1038/s41598-021-91794-z |
| الإتاحة: | https://doi.org/10.1038/s41598-021-91794-zTest https://digitalscholar.lsuhsc.edu/som_facpubs/193Test https://digitalscholar.lsuhsc.edu/context/som_facpubs/article/1192/viewcontent/CalandriaM_ElovanoidsDownregulateSars_20210610.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.9DC5105E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-91794-z |
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