مؤتمر
Adolescence is a time of accelerated vascular ageing in type 1 diabetes: initial findings from the AdDIT Follow-Up Study
| العنوان: | Adolescence is a time of accelerated vascular ageing in type 1 diabetes: initial findings from the AdDIT Follow-Up Study |
|---|---|
| المؤلفون: | Chiesa, Scott, Benitez-Aguirre, Paul, Cameron, Fergus J, Craig, Maria, Couper, Jennifer J, Davis, Elizabeth A, Dalton, R Neil, Daneman, Denis, Donaghue, Kim C, Jones, Timothy J, Mahmud, Farid H, Marshall, Sally M, Neil, H Andrew, Deanfield, John E, Marcovecchio, M Loredana |
| المصدر: | Presented at: ISPAD 23, Rotterdam, Netherlands. (2023) |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | type 1 diabetes, vascular ageing, adolescents |
| الوصف: | Introduction: Childhood-onset type 1 diabetes (T1D) is associated with an increased risk of premature cardiovascular mortality. / Objectives: This study aimed to assess the evolution of subclinical vascular damage in young people with T1D as they transitioned through adolescence. / Methods: Repeated vascular phenotyping was performed in early adolescence (age 13), late adolescence (age 17), and young adulthood (age 23) in 288 adolescents with T1D (52% male) recruited to the Adolescent Type 1 Diabetes Intervention Trial Follow-Up Study (AdDIT Follow-Up). Carotid remodelling was assessed via measures of lumen diameter, intima-media thickness (IMT), and beta stiffness index; aortic stiffness via carotid-femoral pulse wave velocity (PWV); and endothelial function via flow-mediated dilation (FMD). Repeated measures ANOVA were used to assess vascular changes over time, and unpaired t-tests used to compare vascular phenotypes measured in young adulthood to an age- and sex-matched group without T1D (n = 292; 49% male). / Results: In individuals with T1D, progressive stiffening of both the carotid artery and aorta was observed across the 9-year follow-up (e.g. PWV mean [95%CI] change = 1.1 [0.9, 1.3] m/s). In the transition from late adolescence to young adulthood, IMT also increased (+0.04 [0.03, 0.06] mm) and FMD decreased (-1.0 [-0.8, -1.2] %). As a result, young adults with T1D had carotid arteries that were narrower, thicker (IMT = +0.3 [0.2, 0.4] mm), and stiffer (beta stiffness index = +0.3 [0.1, 0.5]) than those without T1D. Aortic stiffness was also higher (PWV = +0.8 [0.6, 0.9] m/s) in T1D, while a compromised FMD (-2.8 [-2.0, -3.6]%) indicated the presence of systemic endothelial dysfunction. / Conclusions: Young people with T1D demonstrate accelerated arterial ageing as they transition adolescence. As a result, these individuals enter young adulthood with arteries that are already smaller, thicker, stiffer, and with evidence of profound endothelial dysfunction when compared to young adults without T1D. |
| نوع الوثيقة: | conference object |
| وصف الملف: | slideshow |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10182152/1/Scott%20Chiesa.pptxTest; https://discovery.ucl.ac.uk/id/eprint/10182152Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10182152/1/Scott%20Chiesa.pptxTest https://discovery.ucl.ac.uk/id/eprint/10182152Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.9D43181A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |