دورية أكاديمية
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report
| العنوان: | Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report |
|---|---|
| المؤلفون: | Connell, Claire M., Brais, Rebecca, Whitaker, Hayley, Upponi, Sara, Beh, Ian, Risdall, Jane, Corrie, Pippa, Janowitz, Tobias, Jodrell, Duncan I. |
| بيانات النشر: | BioMed Central BMC Cancer |
| سنة النشر: | 2020 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Case Report, Medical and radiation oncology, Cytidine deaminase, Drug metabolism, Gemcitabine, Pancreatic adenosquamous carcinoma |
| الوصف: | Funder: Cambridge Experimental Medicine Initiative ; Funder: Cancer Research United Kingdom ; Abstract: Background: Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancreatic adenosquamous carcinoma is largely unknown. Case presentation: We describe the case of a 51 year old woman with pancreatic adenosquamous carcinoma who, following surgical resection, experienced early disease relapse during adjuvant gemcitabine therapy. Paradoxically, this was followed by an exceptional response to capecitabine therapy lasting 34.6 months. Strong expression of cytidine deaminase was detected within the tumour. Conclusions: This case study demonstrates that early relapse during adjuvant chemotherapy for pancreatic adenosquamous carcinoma may be compatible with a subsequent exceptional response to second line chemotherapy, an important observation given the poor overall prognosis of patients with adenosquamous carcinoma. Cytidine deaminase is predicted to inactivate gemcitabine and, conversely, catalyze capecitabine activation. We discuss strong intra-tumoural expression of cytidine deaminase as a potential mechanism to explain this patient’s disparate responses to gemcitabine and capecitabine therapy, and highlight the benefit that may be gained from considering similar determinants of response to chemotherapy in clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/xml; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/306440Test |
| DOI: | 10.17863/CAM.53520 |
| الإتاحة: | https://doi.org/10.17863/CAM.53520Test https://www.repository.cam.ac.uk/handle/1810/306440Test |
| حقوق: | Attribution 4.0 International (CC BY 4.0) ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.9D378B6D |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.53520 |
|---|