التفاصيل البيبلوغرافية
| العنوان: |
Genetic studies of body mass index yield new insights for obesity biology |
| المؤلفون: |
Locke, A.E., Kahali, B., Berndt, S.I., Justice, A.E., Pers, T.H., Day, F.R., Powell, C., Vedantam, S., Buchkovich, M.L., Yang, J., Croteau-Chonka, D.C., Esko, T., Fall, T., Ferreira, T., Gustafsson, S., Kutalik, Z., Luan, J., Mägi, R., Randall, J.C., Winkler, T.W., Wood, A.R., Workalemahu, T., Faul, J.D., Smith, J.A., Hua Zhao, J., Zhao, W., Chen, J., Fehrmann, R., Hedman, Å.K., Karjalainen, J., Schmidt, E.M., Absher, D., Amin, N., Anderson, D., Beekman, M., Bolton, J.L., Bragg-Gresham, J.L., Buyske, S., Demirkan, A., Deng, G., Ehret, G.B., Feenstra, B., Feitosa, M.F., Fischer, K., Goel, A., Gong, J., Jackson, A.U., Kanoni, S., Kleber, M.E., Kristiansson, K., Lim, U., Lotay, V., Mangino, M., Mateo Leach, I., Medina-Gomez, C., Medland, S.E., Nalls, M.A., Palmer, C.D., Pasko, D., Pechlivanis, S., Peters, M.J., Prokopenko, I., Shungin, D., Stančáková, A., Strawbridge, R.J., Ju Sung, Y., Tanaka, T., Teumer, A., Trompet, S., van der Laan, S.W., van Setten, J., Van Vliet-Ostaptchouk, J.V., Wang, Z., Yengo, L., Zhang, W., Isaacs, A., Albrecht, E., Ärnlöv, J., Arscott, G.M., Attwood, A.P., Bandinelli, S., Barrett, A., Bas, I.N., Bellis, C., Bennett, A.J., Berne, C., Blagieva, R., Blüher, M., Böhringer, S., Bonnycastle, L.L., Böttcher, Y., Boyd, H.A., Bruinenberg, M., Caspersen, I.H., Ida Chen, Y.D., Clarke, R., Daw, E.W., de Craen, A.J., Delgado, G., Dimitriou, M., Doney, A.S., Eklund, N., Estrada, K., Eury, E., Folkersen, L., Fraser, R.M., Garcia, M.E., Geller, F., Giedraitis, V., Gigante, B., Go, A.S., Golay, A., Goodall, A.H., Gordon, S.D., Gorski, M., Grabe, H.J., Grallert, H., Grammer, T.B., Gräßler, J., Grönberg, H., Groves, C.J., Gusto, G., Haessler, J., Hall, P., Haller, T., Hallmans, G., Hartman, C.A., Hassinen, M., Hayward, C., Heard-Costa, N.L., Helmer, Q., Hengstenberg, C., Holmen, O., Hottenga, J.J., James, A.L., Jeff, J.M., Johansson, Å., Jolley, J., Juliusdottir, T., Kinnunen, L., Koenig, W., Koskenvuo, M., Kratzer, W., Laitinen, J., Lamina, C., Leander, K., Lee, N.R., Lichtner, P., Lind, L., Lindström, J., Sin Lo, K., Lobbens, S., Lorbeer, R., Lu, Y., Mach, F., Magnusson, P.K., Mahajan, A., McArdle, W.L., McLachlan, S., Menni, C., Merger, S., Mihailov, E., Milani, L., Moayyeri, A., Monda, K.L., Morken, M.A., Mulas, A., Müller, G., Müller-Nurasyid, M., Musk, A.W., Nagaraja, R., Nöthen, M.M., Nolte, I.M., Pilz, S., Rayner, N.W., Renstrom, F., Rettig, R., Ried, J.S., Ripke, S., Robertson, N.R., Rose, L.M., Sanna, S., Scharnagl, H., Scholtens, S., Schumacher, F.R., Scott, W.R., Seufferlein, T., Shi, J., Vernon Smith, A., Smolonska, J., Stanton, A.V., Steinthorsdottir, V., Stirrups, K., Stringham, H.M., Sundström, J., Swertz, M.A., Swift, A.J., Syvänen, A.C., Tan, S.T., Tayo, B.O., Thorand, B., Thorleifsson, G., Tyrer, J.P., Uh, H.W., Vandenput, L., Verhulst, F.C., Vermeulen, S.H., Verweij, N., Vonk, J.M., Waite, L.L., Warren, H.R., Waterworth, D., Weedon, M.N., Wilkens, L.R., Willenborg, C., Wilsgaard, T., Wojczynski, M.K., Wong, A., Wright, A.F., Zhang, Q., Brennan, E.P., Choi, M., Dastani, Z., Drong, A.W., Eriksson, P., Franco-Cereceda, A., Gådin, J.R., Gharavi, A.G., Goddard, M.E., Handsaker, R.E., Huang, J., Karpe, F., Kathiresan, S., Keildson, S., Kiryluk, K., Kubo, M., Lee, J.Y., Liang, L., Lifton, R.P., Ma, B., McCarroll, S.A., McKnight, A.J., Min, J.L., Moffatt, M.F., Montgomery, G.W., Murabito, J.M., Nicholson, G., Nyholt, D.R., Okada, Y., Perry, J.R., Dorajoo, R., Reinmaa, E., Salem, R.M., Sandholm, N., Scott, R.A., Stolk, L., Takahashi, A., Van't Hooft, F.M., Vinkhuyzen, A.A., Westra, H.J., Zheng, W., Zondervan, K.T., GLGC, ICBP, Heath, A.C., Arveiler, D., Bakker, S.J., Beilby, J., Bergman, R.N., Blangero, J., Bovet, P., Campbell, H., Caulfield, M.J., Cesana, G., Chakravarti, A., Chasman, D.I., Chines, P.S., Collins, F.S., Crawford, D.C., Cupples, L.A., Cusi, D., Danesh, J., de Faire, U., den Ruijter, H.M., Dominiczak, A.F., Erbel, R., Erdmann, J., Eriksson, J.G., Farrall, M., Felix, S.B., Ferrannini, E., Ferrières, J., Ford, I., Forouhi, N.G., Forrester, T., Franco, O.H., Gansevoort, R.T., Gejman, P.V., Gieger, C., Gottesman, O., Gudnason, V., Gyllensten, U., Hall, A.S., Harris, T.B., Hattersley, A.T., Hicks, A.A., Hindorff, L.A., Hingorani, A.D., Hofman, A., Homuth, G., Hovingh, G.K., Humphries, S.E., Hunt, S.C., Hyppönen, E., Illig, T., Jacobs, K.B., Jarvelin, M.R., Jöckel, K.H., Johansen, B., Jousilahti, P., Jukema, J.W., Jula, A.M., Kaprio, J., Kastelein, J.J., Keinanen-Kiukaanniemi, S.M., Kiemeney, L.A., Knekt, P., Kooner, J.S., Kooperberg, C., Kovacs, P., Kraja, A.T., Kumari, M., Kuusisto, J., Lakka, T.A., Langenberg, C., Le Marchand, L., Lehtimäki, T., Lyssenko, V., Männistö, S., Marette, A., Matise, T.C., McKenzie, C.A., McKnight, B., Moll, F.L., Morris, A.D., Morris, A.P., Murray, J.C., Nelis, M., Ohlsson, C., Oldehinkel, A.J., Ong, K.K., Madden, P.A., Pasterkamp, G., Peden, J.F., Peters, A., Postma, D.S., Pramstaller, P.P., Price, J.F., Qi, L., Raitakari, O.T., Rankinen, T., Rao, D.C., Rice, T.K., Ridker, P.M., Rioux, J.D., Ritchie, M.D., Rudan, I., Salomaa, V., Samani, N.J., Saramies, J., Sarzynski, M.A., Schunkert, H., Schwarz, P.E., Sever, P., Shuldiner, A.R., Sinisalo, J., Stolk, R.P., Strauch, K., Tönjes, A., Trégouët, D.A., Tremblay, A., Tremoli, E., Virtamo, J., Vohl, M.C., Völker, U., Waeber, G., Willemsen, G., Witteman, J.C., Zillikens, M.C., Adair, L.S., Amouyel, P., Asselbergs, F.W., Assimes, T.L., Bochud, M., Boehm, B.O., Boerwinkle, E., Bornstein, S.R., Bottinger, E.P., Bouchard, C., Cauchi, S., Chambers, J.C., Chanock, S.J., Cooper, R.S., de Bakker, P.I., Dedoussis, G., Ferrucci, L., Franks, P.W., Froguel, P., Groop, L.C., Haiman, C.A., Hamsten, A., Hui, J., Hunter, D.J., Hveem, K., Kaplan, R.C., Kivimaki, M., Kuh, D., Laakso, M., Liu, Y., Martin, N.G., März, W., Melbye, M., Metspalu, A., Moebus, S., Munroe, P.B., Njølstad, I., Oostra, B.A., Palmer, C.N., Pedersen, N.L., Perola, M., Pérusse, L., Peters, U., Power, C., Quertermous, T., Rauramaa, R., Rivadeneira, F., Saaristo, T.E., Saleheen, D., Sattar, N., Schadt, E.E., Schlessinger, D., Slagboom, P.E., Snieder, H., Spector, T.D., Thorsteinsdottir, U., Stumvoll, M., Tuomilehto, J., Uitterlinden, A.G., Uusitupa, M., van der Harst, P., Walker, M., Wallaschofski, H., Wareham, N.J., Watkins, H., Weir, D.R., Wichmann, H.E., Wilson, J.F., Zanen, P., Borecki, I.B., Deloukas, P., Fox, C.S., Heid, I.M., O'Connell, J.R., Strachan, D.P., Stefansson, K., van Duijn, C.M., Abecasis, G.R., Franke, L., Frayling, T.M., McCarthy, M.I., Visscher, P.M., Scherag, A., Willer, C.J., Boehnke, M., Mohlke, K.L., Lindgren, C.M., Beckmann, J.S., Barroso, I., North, K.E., Ingelsson, E., Hirschhorn, J.N., Loos, R.J., Speliotes, E.K. |
| المساهمون: |
LifeLines Cohort Study, ADIPOGen Consortium, AGEN-BMI Working Group, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, MAGIC Investigators, MuTHER Consortium, MIGen Consortium, PAGE Consortium, ReproGen Consortium, GENIE Consortium, International Endogene Consortium, GLGC, ICBP, Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, TL., Thompson, JR., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, BA., Stirrups, K., König, IR., Cazier, JB., Johansson£££Åsa£££ Å., Hall, AS., Lee, JY., Willer, CJ., Chambers, JC., Esko£££Tõnu£££ T., Folkersen, L., Goel, A., Grundberg, E., Havulinna, AS., Ho, WK., Hopewell, JC., Eriksson, N., Kleber, ME., Kristiansson, K., Lundmark, P., Lyytikäinen, LP., Rafelt, S., Shungin, D., Strawbridge, RJ., Thorleifsson, G., Tikkanen, E., Van Zuydam, N., Voight, BF., Waite, LL., Zhang, W., Ziegler, A., Absher, D., Altshuler, D., Balmforth, AJ., Barroso£££Inês£££ I., Braund, PS., Burgdorf, C., Claudi-Boehm, S., Cox, D., Dimitriou, M., Do, R., Doney, AS., El Mokhtari, N., Eriksson, P., Fischer, K., Fontanillas, P., Franco-Cereceda, A., Gigante, B., Groop, L., Gustafsson, S., Hager, J., Hallmans, G., Han, BG., Hunt, SE., Kang, HM., Illig, T., Kessler, T., Knowles, JW., Kolovou, G., Kuusisto, J., Langenberg, C., Langford, C., Leander, K., Lokki, ML., Lundmark, A., McCarthy, MI., Meisinger, C., Melander, O., Mihailov, E., Maouche, S., Morris, AD., Müller-Nurasyid, M., Nikus, K., Peden, JF., Rayner, NW., Rasheed, A., Rosinger, S. |
| المصدر: |
Nature, vol. 518, no. 7538, pp. 197-206 |
| سنة النشر: |
2015 |
| المجموعة: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: |
Body Mass Index, Genome-Wide Association Study, Obesity/genetics, Obesity/metabolism |
| الوصف: |
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0028-0836 |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pmid/25673413; info:eu-repo/semantics/altIdentifier/eissn/1476-4687; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F373E38AD7603; https://serval.unil.ch/notice/serval:BIB_F373E38AD760Test; urn:issn:0028-0836; https://serval.unil.ch/resource/serval:BIB_F373E38AD760.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F373E38AD7603Test |
| DOI: |
10.1038/nature14177 |
| الإتاحة: |
https://doi.org/10.1038/nature14177Test
https://serval.unil.ch/notice/serval:BIB_F373E38AD760Test
https://serval.unil.ch/resource/serval:BIB_F373E38AD760.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F373E38AD7603Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimerTest |
| رقم الانضمام: |
edsbas.9D1F90B0 |
| قاعدة البيانات: |
BASE |
