مؤتمر
USING BOTULINUM TOXIN FOR THE TREATMENT OF GASTROPARESIS (GP) FOR THE SELECTION OF PATIENTS WITH HIGHER CLINICAL SUCCESS, IMPROVED QUALITY OF LIFE (QOL), AND IMPROVED SOCIAL FUNCTIONING POST GASTRIC PERORAL ENDOSCOPIC MYOTOMY (GPOEM)
| العنوان: | USING BOTULINUM TOXIN FOR THE TREATMENT OF GASTROPARESIS (GP) FOR THE SELECTION OF PATIENTS WITH HIGHER CLINICAL SUCCESS, IMPROVED QUALITY OF LIFE (QOL), AND IMPROVED SOCIAL FUNCTIONING POST GASTRIC PERORAL ENDOSCOPIC MYOTOMY (GPOEM) |
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| المؤلفون: | Kais, Amr, Al-Haddad, Mohammad |
| سنة النشر: | 2023 |
| المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: | GPOEM, Gastroparesis, Botox, Intrapyloric Botulinum Toxin, Gastric Per Oral Endoscopic Myotomy, Gastric Botox, Endoscopy, Myotomy, Gastroenterology |
| الوصف: | BACKGROUND While G-POEM remains an effective and exciting treatment for GP patients, predictors of clinical success remain poorly characterized. Botox injection of the pylorus prior to committing to G POEM can help differentiate those who might have a favorable clinical response to this procedure in patients with GP. METHODS To evaluate the utility of Botox injection prior to G-POEM, 124 patients with clinically diagnosed GP who underwent a GPOEM were assessed in this retrospective cohort study. All G-POEM procedures were conducted at a single center and were completed between February 2018 and May 2023. Patients who had received intrapyloric Botox injection (n=79) had QoL and clinical success rates compared to patients who received other treatment options (n=45). Results were assessed at 1-, 3-, 6-, 12-, 24-, 36-, 48-months post G-POEM. RESULTS When assessing symptom severity, the difference between the change in GCSI values for Botox patients and patients receiving other prior therapy was statistically significant at 6 months post GPOEM; +1.27 for Botox patients vs +0.55 for other treatments (p-value of 0.03). At this 6-month checkpoint, 64% of the Botox group achieved clinical success compared to 37.5% for the other treatment group. When comparing QoL, intrapyloric Botox injection has statistically significant improvements in SF-36 total score at 1, 3-, 6-, 12-, and 36-months post G-POEM, while patients receiving other treatments had no statistically significant improvements in their SF-36 total scores. CONCLUSION We hypothesize that clinical improvement on pre GPOEM Botox selects patients with a higher component of pyloric spasm who end up responding more favorably to GPOEM. IMPLICATIONS Intrapyloric Botox injection is technically feasible in almost all patients with GP and does not require special expertise, training, or equipment; therefore, this should be strongly considered prior to referring a patient for G-POEM. |
| نوع الوثيقة: | conference object still image |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.presentationml.presentation |
| اللغة: | English |
| العلاقة: | Kais A, Al-Haddad M. Using Botulinum Toxin for the Treatment of Gastroparesis (GP) Post Gastric Peroral Endoscopic Myotomy (GPOEM) Knowledge and Intent to Use among IUPUI Students. Poster presented at: Indiana University Medical Student Program for Research and Scholarship (IMPRS) Research Symposium; July 27-28, 2023; Indianapolis, IN.; https://hdl.handle.net/1805/35806Test |
| الإتاحة: | https://hdl.handle.net/1805/35806Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.9D1E6865 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |