دورية أكاديمية
TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis
العنوان: | TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis |
---|---|
المؤلفون: | Conrad, Curdin, Di Domizio, Jeremy, Mylonas, Alessio, Belkhodja, Cyrine, Demaria, Olivier, Navarini, Alexander A, Lapointe, Anne-Karine, French, Lars E, Vernez, Maxime, Gilliet, Michel |
المصدر: | Conrad, Curdin; Di Domizio, Jeremy; Mylonas, Alessio; Belkhodja, Cyrine; Demaria, Olivier; Navarini, Alexander A; Lapointe, Anne-Karine; French, Lars E; Vernez, Maxime; Gilliet, Michel (2018). TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis. Nature Communications, 9(1):25. |
بيانات النشر: | Nature Publishing Group |
سنة النشر: | 2018 |
المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
مصطلحات موضوعية: | Dermatology Clinic, 610 Medicine & health |
الوصف: | Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2-5% of treated patients develop psoriasis-like skin lesions called paradoxical psoriasis. The pathogenesis of this side effect and its distinction from classical psoriasis remain unknown. Here we show that skin lesions from patients with paradoxical psoriasis are characterized by a selective overexpression of type I interferons, dermal accumulation of plasmacytoid dendritic cells (pDC), and reduced T-cell numbers, when compared to classical psoriasis. Anti-TNF treatment prolongs type I interferon production by pDCs through inhibition of their maturation. The resulting type I interferon overexpression is responsible for the skin phenotype of paradoxical psoriasis, which, unlike classical psoriasis, is independent of T cells. These findings indicate that paradoxical psoriasis represents an ongoing overactive innate inflammatory process, driven by pDC-derived type I interferon that does not lead to T-cell autoimmunity. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 2041-1723 |
العلاقة: | https://www.zora.uzh.ch/id/eprint/150972/1/2018_LF_TNF_blockade_induces_a_dysregulated_type_I_interferon_response_without_autoimmunity_in_paradoxical_psoriasis.pdfTest; info:pmid/29295985; urn:issn:2041-1723 |
DOI: | 10.5167/uzh-150972 |
DOI: | 10.1038/s41467-017-02466-4 |
الإتاحة: | https://doi.org/10.5167/uzh-15097210.1038/s41467-017-02466-4Test https://www.zora.uzh.ch/id/eprint/150972Test/ https://www.zora.uzh.ch/id/eprint/150972/1/2018_LF_TNF_blockade_induces_a_dysregulated_type_I_interferon_response_without_autoimmunity_in_paradoxical_psoriasis.pdfTest |
حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ |
رقم الانضمام: | edsbas.9CA7F700 |
قاعدة البيانات: | BASE |
تدمد: | 20411723 |
---|---|
DOI: | 10.5167/uzh-150972 |