دورية أكاديمية
A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition.
| العنوان: | A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. |
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| المساهمون: | Jae Yeon Seok, Deuk Chae Na, Hyun Goo Woo, Massimo Roncalli, So Mee Kwon, Jeong Eun Yoo, Ei Yong Ahn, Gwang Il Kim, Jin-Sub Choi, Young Bae Kim, Young Nyun Park, Ahn, Ei Yong, Yoo, Jeong Eun, Choi, Jin Sub, Kim, Gwang Il, Na, Deuk Chae, Park, Young Nyun, Seok, Jae Yeon |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Bile Duct Neoplasms/genetics, Bile Duct Neoplasms/mortality, Bile Duct Neoplasms/pathology, Bile Ducts, Intrahepatic, Carcinoma, Hepatocellular/mortality, Hepatocellular/pathology, Cholangiocarcinoma/genetics, Cholangiocarcinoma/mortality, Cholangiocarcinoma/pathology, Epithelial-Mesenchymal Transition, Female, Fibrosis, Gene Expression Profiling, Humans, Liver Neoplasms/mortality, Liver Neoplasms/pathology, Male, Middle Aged, Signal Transduction, Transforming Growth Factor beta/physiology |
| الوصف: | Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major primary liver cancers in adults. The phenotypic overlap between HCC and CC has been shown to comprise a continuous liver cancer spectrum. As a proof of this concept, a recent study demonstrated a genomic subtype of HCC that expressed CC-like gene expression traits, such as CC-like HCC, which revealed the common genomic trait of stem-cell-like properties and aggressive clinical outcomes. Scirrhous HCC (S-HCC), a rare variant of HCC, is characterized by abundant fibrous stroma and has been known to express several liver stem/progenitor cell markers. This suggests that S-HCC may harbor common intermediate traits between HCC and CC, including stem-cell traits, which are similar to those of CC-like HCC. However, the molecular and pathological characteristics of S-HCC have not been fully evaluated. By performing gene-expression profiling and immunohistochemical evaluation, we compared the morphological and molecular features of S-HCC with those of CC and HCC. S-HCC expresses both CC-like and stem-cell-like genomic traits. In addition, we observed the expression of core epithelial-mesenchymal transition (EMT)-related genes, which may contribute to the aggressive behavior of S-HCC. Overexpression of transforming growth factor beta (TGF-棺) signaling was also found, implying its regulatory role in the pathobiology of S-HCC. Conclusion: We suggest that the fibrous stromal component in HCC may contribute to the acquisition of CC-like gene-expression traits in HCC. The expression of stem-cell-like traits and TGF-棺/EMT molecules may play a pivotal role in the aggressive phenotyping of S-HCC. (HEPATOLOGY 2012;55:1776-1786). ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0270-9139 1527-3350 |
| العلاقة: | HEPATOLOGY; J00985; OAK-2012-00702; https://ir.ymlib.yonsei.ac.kr/handle/22282913/90360Test; T201201496; HEPATOLOGY, Vol.55(6) : 1776-1786, 2012 |
| DOI: | 10.1002/hep.25570/abstract |
| الإتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90360Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.9C8563D5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02709139 15273350 |
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| DOI: | 10.1002/hep.25570/abstract |