التفاصيل البيبلوغرافية
| العنوان: |
A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer |
| المؤلفون: |
Wang, Victoria, Geybels, Milan S., Jordahl, Kristina M., Gerke, Travis, Hamid, Anis, Penney, Kathryn L., Markt, Sarah C., Freedman, Matthew, Pomerantz, Mark, Lee, Gwo‐Shu M., Rana, Huma, Börnigen, Daniela, Rebbeck, Timothy R., Huttenhower, Curtis, Eeles, Ros A., Stanford, Janet L., Consortium, Practical, Berndt, Sonja I., Claessens, Frank, Sørensen, Karina D., Park, Jong Y., Vega, Ana, Usmani, Nawaid, Mucci, Lorelei, Sweeney, Christopher J. |
| المساهمون: |
Congressionally Directed Medical Research Programs |
| المصدر: |
The Prostate ; volume 81, issue 10, page 683-693 ; ISSN 0270-4137 1097-0045 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background Inflammation and one of its mediators, NF‐kappa B (NFκB), have been implicated in prostate cancer carcinogenesis. We assessed whether germline polymorphisms associated with NFκB are associated with the risk of developing lethal disease (metastases or death from prostate cancer). Methods Using a Bayesian approach leveraging NFκB biology with integration of publicly available datasets we used a previously defined genome‐wide functional association network specific to NFκB and lethal prostate cancer. A dense‐module‐searching method identified modules enriched with significant genes from a genome‐wide association study (GWAS) study in a discovery data set, Physicians' Health Study and Health Professionals Follow‐up Study (PHS/HPFS). The top 48 candidate single nucleotide polymorphisms (SNPs) from the dense‐module‐searching method were then assessed in an independent prostate cancer cohort and the one SNP reproducibly associated with lethality was tested in a third cohort. Logistic regression models evaluated the association between each SNP and lethal prostate cancer. The candidate SNP was assessed for association with lethal prostate cancer in 6 of 28 studies in the prostate cancer association group to investigate cancer associated alterations in the genome (PRACTICAL) Consortium where there was some medical record review for death ascertainment which also had SNP data from the ONCOARRAY platform. All men self‐identified as Caucasian. Results The rs1910301 SNP which was reproducibly associated with lethal disease was nominally associated with lethal disease (odds ratio [OR] = 1.40; p = .02) in the discovery cohort and the minor allele was also associated with lethal disease in two independent cohorts (OR = 1.35; p = .04 and OR = 1.35; p = .07). Fixed effects meta‐analysis of all three cohorts found an association: OR = 1.37 (95% confidence interval [CI]: 1.15–1.62, p = .0003). This SNP is in the promoter region of FRAS1 , a gene involved in epidermal‐basement membrane adhesion and is present at ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/pros.24148 |
| الإتاحة: |
https://doi.org/10.1002/pros.24148Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#amTest ; http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.9C6BED7D |
| قاعدة البيانات: |
BASE |
