التفاصيل البيبلوغرافية
| العنوان: |
Is decision-making impairment an endophenotype of Anorexia Nervosa? |
| المؤلفون: |
Di Lodovico, L., Lachatre, M., Marcheselli, J., Versini, A., Ramoz, N., Gorwood, P. |
| المصدر: |
Eur Psychiatry |
| بيانات النشر: |
Cambridge University Press |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Abstract, psy, socio |
| الوصف: |
INTRODUCTION: Patients with anorexia nervosa (AN) show impaired decision-making ability, but it is still unclear if this is a trait marker, i.e. a stable endophenotype of AN, or a state parameter, i.e. being explained by present symptoms and associated comorbidity. OBJECTIVES: We aimed to determine whether decision-making impairment is an endophenotype of AN. We hypothesized that decision-making alteration would not respect the criteria of an endophenotype, and that these alterations would have a relationship with illness severity. METHODS: Ninety-one patients with acute AN (A-AN), 90 unaffected relatives (UR), 23 patients remitted from AN (R-AN) and 204 healthy controls (HC) underwent the Iowa Gambling Task (IGT) and psychometric assessments. Prospective Valence Learning model (PVL) was employed to distinguish the cognitive dimensions underlying the decision-making process. Performance at the IGT was compared between the four groups and then analysed according to clinical and psychometric variables. RESULTS: Patients with A-AN scored worse than UR and HC at the IGT (p<.01). PVL-feedback sensitivity parameter was lower in patients with R-AN and A-AN than in the two other groups (p<.01) and PVL-loss aversion parameter was lower in A-AN than in UR and R-AN (p<.01). Decision-making style, in particular learning and loss aversion parameters, accounted for a significant part of variance of psychopathology in patients with AN (p<.01). CONCLUSIONS: Impaired decision-making represents a state-associated, cognitive hallmark of AN. The aggravation of reward modulation along with illness progression may explain the persistence of symptoms despite their consequences on health. Reversal of decision-making impairment should not be limited by inherited vulnerability. DISCLOSURE: No significant relationships. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565964Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565964Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.9C6049A4 |
| قاعدة البيانات: |
BASE |
