دورية أكاديمية
Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients
| العنوان: | Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients |
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| المؤلفون: | Lichtner, Miriam, Cicconi, Paola, Vita, Serena, Cozzi-Lepri, Alessandro, Galli, Massimo, Lo Caputo, Sergio, Saracino, Annalisa, De Luca, Andrea, Moioli, Mariacristina, Maggiolo, Franco, Marchetti, Giulia, Vullo, Vincenzo, D'arminio Monforte, Antonella, on behalf of the Icona Foundation Study Group, Castagna, Antonella |
| المساهمون: | Lichtner, Miriam, Cicconi, Paola, Vita, Serena, Cozzi-Lepri, Alessandro, Galli, Massimo, Lo Caputo, Sergio, Saracino, Annalisa, De Luca, Andrea, Moioli, Mariacristina, Maggiolo, Franco, Marchetti, Giulia, Vullo, Vincenzo, D'arminio Monforte, Antonella, on behalf of the Icona Foundation Study, Group, Castagna, Antonella |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | cardiovascular/cerebrovascular event, CMV infection, HIV infection, morbidity, mortality, severe non-AIDS-defining event, AIDS-Related Opportunistic Infection, Adult, Antibodies, Viral, Cardiovascular Disease, Cerebrovascular Disorder, Cohort Studie, Cross-Sectional Studie, Cytomegalovirus Infection, Female, Human, Immunoglobulin G, Male, Prospective Studie, Risk Assessment, Infectious Disease, Immunology and Allergy, Medicine (all) |
| الوصف: | Background Chronic cytomegalovirus (CMV) infection has been associated with immunosenescence and immunoactivation in the general population. In human immunodeficiency virus type 1 (HIV-1)-infected people, CMV coinfection, in addition to residual HIV replication and microbial translocation, has been proposed as a key factor in sustaining immune activation, even in individuals with a controlled HIV load. Methods Patients from the ICONA Study with at least 1 CMV immunoglobulin G (IgG) test available without active CMV disease were included in the analysis. AIDS-defining event or AIDS-related death and severe non-AIDS-defining event or non-AIDS-related death were taken as clinical progression end points. Independent predictors of CMV were identified by multivariable logistic regression. Probabilities of reaching the end points were estimated by survival analyses. Results A total of 6111 subjects were included, of whom 5119 (83.3%) were CMV IgG positive at baseline. Patients with CMV IgG positivity at baseline were more likely to develop a severe non-AIDS-defining event/non-AIDS-related death (adjusted hazard ratio [HR], 1.53 [95% confidence interval CI, 1.08-2.16]. In particular, CMV seropositivity was an independent risk factor for cardiovascular and cerebrovascular diseases (adjusted HR, 2.27 [95% CI,. 97-5.32]). Conclusions In our study population, CMV/HIV coinfection was associated with the risk of severe non-AIDS-defining events/non-AIDS-related death, especially with cardiovascular and cerebrovascular events, independently of other prognostic factors. This finding supports a potential independent role of CMV coinfection in vascular/degenerative organ disorders in HIV-infected subjects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000350221000004; volume:211; issue:2; firstpage:178; lastpage:186; numberofpages:9; journal:THE JOURNAL OF INFECTIOUS DISEASES; http://hdl.handle.net/20.500.11768/68161Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84922513716; http://jid.oxfordjournals.org/content/currentTest |
| DOI: | 10.1093/infdis/jiu417 |
| الإتاحة: | https://doi.org/20.500.11768/68161Test https://doi.org/10.1093/infdis/jiu417Test https://hdl.handle.net/20.500.11768/68161Test http://jid.oxfordjournals.org/content/currentTest |
| رقم الانضمام: | edsbas.9C5D80EE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/jiu417 |
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