Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries.

التفاصيل البيبلوغرافية
العنوان:	Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries.
المؤلفون:	Fabian, Ido Didi, Stacey, Andrew W, Foster, Allen, Kivelä, Tero T, Munier, Francis L, Keren-Froim, Naama, Gomel, Nir, Cassoux, Nathalie, Sagoo, Mandeep S, Reddy, M Ashwin, Harby, Lamis Al, Zondervan, Marcia, Bascaran, Covadonga, Abdallah, Elhassan, Abdullahi, Shehu U, Boubacar, Sahadatou Adamou, Ademola-Popoola, Dupe S, Adio, Adedayo, Aghaji, Ada E, Portabella, Silvia Alarcón, Alfa Bio, Amadou I, Ali, Amany M, Alia, Donjeta B, All-Eriksson, Charlotta, Almeida, Argentino A, Alsawidi, Khalifa M, Antonino, Romanzo, Astbury, Nicholas J, Atsiaya, Rose, Balaguer, Julia, Balwierz, Walentyna, Barranco, Honorio, Popovic, Maja Beck, Benmiloud, Sarra, Guebessi, Nissrine Bennani, Berete, Rokia C, Biddulph, Shelley J, Biewald, Eva M, Blum, Sharon, Bobrova, Nadia, Boehme, Marianna, Bornfeld, Norbert, Bouda, Gabrielle C, Bouguila, Hédi, Boumedane, Amaria, Brichard, Bénédicte G, L, Michael Capra, Castela, Guilherme, Català-Mora, Jaume, Chantada, Guillermo L, Chernodrinska, Violeta S, Chiwanga, Faraja S, Cieslik, Krzysztof, Comsa, Codruta, Correa Llano, Maria G, Csóka, Monika, Da Gama, Isac V, Davidson, Alan, Potter, Patrick De, Desjardins, Laurence, Dragomir, Monica D, Bruyn, Magritha Du, Kettani, Asmaa El, Elbahi, Amal M, Elgalaly, Dina, Elhaddad, Alaa M, Ali Elhassan, Moawia M, Elzembely, Mahmoud M, Essuman, Vera A, Evina, Ted Grimbert A, Fasina, Oluyemi, Fernández-Teijeiro, Ana, Gandiwa, Moira, Aldana, David García, Geel, Jennifer A, Gizachew, Zelalem, Gregersen, Pernille A, Guedenon, Koffi M, Hadjistilianou, Theodora, Hassan, Sadiq, Hederova, Stanislava, Hessissen, Laila, Hordofa, Diriba F, Hummlen, Marlies, Husakova, Kristina, Ida, Russo, Ilic, Vesna R, Jenkinson, Helen, Amani Kabesha, Theophile B, Kabore, Rolande L, Kalinaki, Abubakar, Kapelushnik, Noa, Kardava, Tamar, Kemilev, Pavlin Kroumov, Kepak, Tomas, Khotenashvili, Zaza, Klett, Artur, Kosh Komba Palet, Jess Elio, Krivaitiene, Dalia, Kruger, Mariana, Kyara, Alice, Lachmann, Eva S, Latinović, Slobodanka, Lecuona, Karin, Lukamba, Robert M, Lumbroso, Livia, Lysytsia, Lesia, Maka, Erika, Makan, Mayuri, Manda, Chatonda, Begue, Nieves Martín, Matende, Ibrahim O, Matua, Marchelo, Mayet, Ismail, Mbumba, Freddy B, Mengesha, Aemero A, Midena, Edoardo, Mndeme, Furahini G, Mohamedani, Ahmed A, Moll, Annette C, Moreira, Claude, Msina, Mchikirwa S, Msukwa, Gerald, Muma, Kangwa I, Murgoi, Gabriela, Musa, Kareem O, Mustak, Hamzah, Muyen, Okwen M, Naidu, Gita, Naumenko, Larisa, Ndoye Roth, Paule Aïda, Neroev, Vladimir, Nikitovic, Marina, Nkanga, Elizabeth D, Nkumbe, Henry, Nyaywa, Mutale, Obono-Obiang, Ghislaine, Oguego, Ngozi C, Olechowski, Andrzej, Oscar, Alexander Hugo, Osei-Bonsu, Peter, Painter, Sally L, Paintsil, Vivian, Paiva, Luisa, Papyan, Ruzanna, Parrozzani, Raffaele, Parulekar, Manoj, Pawinska-Wasikowska, Katarzyna, Perić, Sanja, Philbert, Remezo, Pochop, Pavel, Polyakov, Vladimir G, Pompe, Manca T, Pons, Jonathan J, Raobela, Léa, Renner, Lorna A, Reynders, David, Ribadu, Dahiru, Riheia, Mussagy M, Ritter-Sovinz, Petra, Saakyan, Svetlana, Said, Azza Ma, Román Pacheco, Sonsoles San, Scanlan, Trish A, Schoeman, Judy, Seregard, Stefan, Sherief, Sadik T, Cheikh, Sidi Sidi, Silva, Sónia, Sorochynska, Tetyana, Ssali, Grace, Stathopoulos, Christina, Kranjc, Branka Stirn, Stones, David K, Svojgr, Karel, Sylla, Fatoumata, Tamamyan, Gevorg, Tandili, Alketa, Tateshi, Bekim, Theophile, Tuyisabe, Traoré, Fousseyni, Tyau-Tyau, Harba, Umar, Ali B, Urbak, Steen F, Ushakova, Tatiana L, Valeina, Sandra, Hoefen Wijsard, Milo van, Veleva-Krasteva, Nevyana V, Viksnins, Maris, Wackernagel, Werner, Waddell, Keith, Wade, Patricia D, Wali Nigeria, Amina H, Wime, Amelia Dc, Dod, Charlotte Wolley, Yanga, Jenny M, Yarovaya, Vera A, Yarovoy, Andrey A, Zein, Ekhtelbenina, Sharabi, Shirley, Zhilyaeva, Katsiaryna, Ziko, Othman Ao, Bowman, Richard
بيانات النشر:	BMJ
سنة النشر:	2020
المجموعة:	London School of Hygiene & Tropical Medicine: LSHTM Research Online
الوصف:	BACKGROUND: The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe. METHODS: A cross-sectional analysis including 518 treatment-naïve patients with retinoblastoma residing in 40 European countries and 1024 treatment-naïve patients with retinoblastoma residing in 43 African countries. RESULTS: Capture rate was 42.2% of expected patients from Africa and 108.8% from Europe. African patients were older (95% CI -12.4 to -5.4, p<0.001), had fewer cases of familial retinoblastoma (95% CI 2.0 to 5.3, p<0.001) and presented with more advanced disease (95% CI 6.0 to 9.8, p<0.001); 43.4% and 15.4% of Africans had extraocular retinoblastoma and distant metastasis at the time of diagnosis, respectively, compared to 2.9% and 1.0% of the Europeans. To reach a retinoblastoma centre, European patients travelled 421.8 km compared to Africans who travelled 185.7 km (p<0.001). On regression analysis, lower-national income level, African residence and older age (p<0.001), but not travel distance (p=0.19), were risk factors for advanced disease. CONCLUSIONS: Fewer than half the expected number of patients with retinoblastoma presented to African referral centres in 2017, suggesting poor awareness or other barriers to access. Despite the relatively shorter distance travelled by African patients, they presented with later-stage disease. Health education about retinoblastoma is needed for carers and health workers in Africa in order to increase capture rate and promote early referral.
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	text
اللغة:	English
العلاقة:	https://researchonline.lshtm.ac.uk/id/eprint/4658215/1/Clean.docxTest; https://researchonline.lshtm.ac.uk/id/eprint/4658215/2/Figure%201A.tifTest; https://researchonline.lshtm.ac.uk/id/eprint/4658215/3/Figure%201B.tifTest; https://researchonline.lshtm.ac.uk/id/eprint/4658215/4/Figure%202.tifTest; Fabian, Ido Didi; Stacey, Andrew W; Foster, Allen ; Kivelä, Tero T; Munier, Francis L; Keren-Froim, Naama; Gomel, Nir; Cassoux, Nathalie; Sagoo, Mandeep S; Reddy, M Ashwin; +193 more. Harby, Lamis Al; Zondervan, Marcia ; Bascaran, Covadonga; Abdallah, Elhassan; Abdullahi, Shehu U; Boubacar, Sahadatou Adamou; Ademola-Popoola, Dupe S; Adio, Adedayo; Aghaji, Ada E; Portabella, Silvia Alarcón; Alfa Bio, Amadou I; Ali, Amany M; Alia, Donjeta B; All-Eriksson, Charlotta; Almeida, Argentino A; Alsawidi, Khalifa M; Antonino, Romanzo; Astbury, Nicholas J ; Atsiaya, Rose; Balaguer, Julia; Balwierz, Walentyna; Barranco, Honorio; Popovic, Maja Beck; Benmiloud, Sarra; Guebessi, Nissrine Bennani; Berete, Rokia C; Biddulph, Shelley J; Biewald, Eva M; Blum, Sharon; Bobrova, Nadia; Boehme, Marianna; Bornfeld, Norbert; Bouda, Gabrielle C; Bouguila, Hédi; Boumedane, Amaria; Brichard, Bénédicte G; L, Michael Capra; Castela, Guilherme; Català-Mora, Jaume; Chantada, Guillermo L; Chernodrinska, Violeta S; Chiwanga, Faraja S; Cieslik, Krzysztof; Comsa, Codruta; Correa Llano, Maria G; Csóka, Monika; Da Gama, Isac V; Davidson, Alan; Potter, Patrick De; Desjardins, Laurence; Dragomir, Monica D; Bruyn, Magritha Du; Kettani, Asmaa El; Elbahi, Amal M; Elgalaly, Dina; Elhaddad, Alaa M; Ali Elhassan, Moawia M; Elzembely, Mahmoud M; Essuman, Vera A; Evina, Ted Grimbert A; Fasina, Oluyemi; Fernández-Teijeiro, Ana; Gandiwa, Moira; Aldana, David García; Geel, Jennifer A; Gizachew, Zelalem; Gregersen, Pernille A; Guedenon, Koffi M; Hadjistilianou, Theodora; Hassan, Sadiq; Hederova, Stanislava; Hessissen, Laila; Hordofa, Diriba F; Hummlen, Marlies; Husakova, Kristina; Ida, Russo; Ilic, Vesna R; Jenkinson, Helen; Amani Kabesha, Theophile B; Kabore, Rolande L; Kalinaki, Abubakar; Kapelushnik, Noa; Kardava, Tamar; Kemilev, Pavlin Kroumov; Kepak, Tomas; Khotenashvili, Zaza; Klett, Artur; Kosh Komba Palet, Jess Elio; Krivaitiene, Dalia; Kruger, Mariana; Kyara, Alice; Lachmann, Eva S; Latinović, Slobodanka; Lecuona, Karin; Lukamba, Robert M; Lumbroso, Livia; Lysytsia, Lesia; Maka, Erika; Makan, Mayuri; Manda, Chatonda; Begue, Nieves Martín; Matende, Ibrahim O; Matua, Marchelo; Mayet, Ismail; Mbumba, Freddy B; Mengesha, Aemero A; Midena, Edoardo; Mndeme, Furahini G; Mohamedani, Ahmed A; Moll, Annette C; Moreira, Claude; Msina, Mchikirwa S; Msukwa, Gerald; Muma, Kangwa I; Murgoi, Gabriela; Musa, Kareem O; Mustak, Hamzah; Muyen, Okwen M; Naidu, Gita; Naumenko, Larisa; Ndoye Roth, Paule Aïda; Neroev, Vladimir; Nikitovic, Marina; Nkanga, Elizabeth D; Nkumbe, Henry; Nyaywa, Mutale; Obono-Obiang, Ghislaine; Oguego, Ngozi C; Olechowski, Andrzej; Oscar, Alexander Hugo; Osei-Bonsu, Peter; Painter, Sally L; Paintsil, Vivian; Paiva, Luisa; Papyan, Ruzanna; Parrozzani, Raffaele; Parulekar, Manoj; Pawinska-Wasikowska, Katarzyna; Perić, Sanja; Philbert, Remezo; Pochop, Pavel; Polyakov, Vladimir G; Pompe, Manca T; Pons, Jonathan J; Raobela, Léa; Renner, Lorna A; Reynders, David; Ribadu, Dahiru; Riheia, Mussagy M; Ritter-Sovinz, Petra; Saakyan, Svetlana; Said, Azza Ma; Román Pacheco, Sonsoles San; Scanlan, Trish A; Schoeman, Judy; Seregard, Stefan; Sherief, Sadik T; Cheikh, Sidi Sidi; Silva, Sónia; Sorochynska, Tetyana; Ssali, Grace; Stathopoulos, Christina; Kranjc, Branka Stirn; Stones, David K; Svojgr, Karel; Sylla, Fatoumata; Tamamyan, Gevorg; Tandili, Alketa; Tateshi, Bekim; Theophile, Tuyisabe; Traoré, Fousseyni; Tyau-Tyau, Harba; Umar, Ali B; Urbak, Steen F; Ushakova, Tatiana L; Valeina, Sandra; Hoefen Wijsard, Milo van; Veleva-Krasteva, Nevyana V; Viksnins, Maris; Wackernagel, Werner; Waddell, Keith; Wade, Patricia D; Wali Nigeria, Amina H; Wime, Amelia Dc; Dod, Charlotte Wolley; Yanga, Jenny M; Yarovaya, Vera A; Yarovoy, Andrey A; Zein, Ekhtelbenina; Sharabi, Shirley; Zhilyaeva, Katsiaryna; Ziko, Othman Ao; Bowman, Richard; (2020) Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries. The British journal of ophthalmology, 105 (10). pp. 1435-1443. ISSN 0007-1161 DOI: https://doi.org/10.1136/bjophthalmol-2020-316613Test
الإتاحة:	https://doi.org/10.1136/bjophthalmol-2020-316613Test https://researchonline.lshtm.ac.uk/id/eprint/4658215Test/ https://researchonline.lshtm.ac.uk/id/eprint/4658215/1/Clean.docxTest https://researchonline.lshtm.ac.uk/id/eprint/4658215/2/Figure%201A.tifTest https://researchonline.lshtm.ac.uk/id/eprint/4658215/3/Figure%201B.tifTest https://researchonline.lshtm.ac.uk/id/eprint/4658215/4/Figure%202.tifTest
حقوق:	cc_by_nc_nd
رقم الانضمام:	edsbas.9C4CD99B
قاعدة البيانات:	BASE

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