دورية أكاديمية
Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans
| العنوان: | Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans |
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| المؤلفون: | Ackermann, Katrin, Plomp, Rosina, Lao, Oscar, Middleton, Benita, Revell, Victoria L, Skene, Debra J, Kayser, Manfred |
| المصدر: | Ackermann , K , Plomp , R , Lao , O , Middleton , B , Revell , V L , Skene , D J & Kayser , M 2013 , ' Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans ' , Chronobiology International , vol. 30 , no. 7 , pp. 901-9 . https://doi.org/10.3109/07420528.2013.784773Test |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | ARNTL Transcription Factors, Adult, Circadian Rhythm, Gene Expression Profiling, Gene Expression Regulation, HSP70 Heat-Shock Proteins, Humans, Hydrocortisone, Leukocytes, Light, Male, Melatonin, Nuclear Receptor Subfamily 1, Group D, Member 1, Oscillometry, Oxidative Stress, Period Circadian Proteins, Radioimmunoassay, Sleep, Sleep Deprivation, Time Factors, Young Adult, Journal Article, Research Support, Non-U.S. Gov't |
| الوصف: | This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3109/07420528.2013.784773 |
| الإتاحة: | https://doi.org/10.3109/07420528.2013.784773Test https://risweb.st-andrews.ac.uk/portal/en/researchoutput/effect-of-sleep-deprivation-on-rhythms-of-clock-gene-expression-and-melatonin-in-humansTest(bcd4591f-115c-43fd-a37c-7554b35315cd).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.9C3FBBAF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3109/07420528.2013.784773 |
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