دورية أكاديمية
Impact of COVID-19 in Immunosuppressed Children With Neuroimmunologic Disorders
| العنوان: | Impact of COVID-19 in Immunosuppressed Children With Neuroimmunologic Disorders |
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| المؤلفون: | Olivé-Cirera, Gemma, Fonseca, Elianet, Cantarín-Extremera, Verónica, Vázquez-López, María, Jiménez-Legido, María, González-Álvarez, Verónica, Ribeiro-Constante, Juliana, Camacho-Salas, Ana, Martí, Itxaso, Martínez-González, María Jesús, Saiz, Albert, Armangué, Thaís |
| سنة النشر: | 2022 |
| المجموعة: | UVaDOC - Repositorio Documental de la Universidad de Valladolid |
| الوصف: | Background and Objectives To investigate whether children receiving immunosuppressive therapies for neuroimmunologic disorders had (1) increased susceptibility to SARS-CoV2 infection or to develop more severe forms of COVID-19; (2) increased relapses or autoimmune complications if infected; and (3) changes in health care delivery during the pandemic. Methods Patients with and without immunosuppressive treatment were recruited to participate in a retrospective survey evaluating the period from March 14, 2020, to March 30, 2021. Demographics, clinical features, type of immunosuppressive treatment, suspected or confirmed COVID-19 in the patients or cohabitants, and changes in care delivery were recorded. Results One hundred fifty-three children were included: 84 (55%) female, median age 13 years (interquartile range [8–16] years), 79 (52%) on immunosuppressive treatment. COVID-19 was suspected or confirmed in 17 (11%) (all mild), with a frequency similar in patients with and without immunosuppressive treatment (11/79 [14%] vs 6/74 [8%], p = 0.3085). The frequency of neurologic relapses was similar in patients with (18%) and without (21%) COVID19. Factors associated with COVID-19 included having cohabitants with COVID-19 (p <0.001) and lower blood levels of vitamin D (p = 0.039). Return to face-to-face schooling or mask type did not influence the risk of infection, although 43(28%) children had contact with a classmate with COVID-19. Clinic visits changed from face to face to remote for 120 (79%) patients; 110 (92%) were satisfied with the change. Discussion In this cohort of children with neuroimmunologic disorders, the frequency of COVID-19 was low and not affected by immunosuppressive therapies. The main risk factors for developing COVID-19 were having cohabitants with COVID-19 and low vitamin D levels |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Spanish; Castilian |
| تدمد: | 2332-7812 |
| العلاقة: | https://doi.org/10.1212/NXI.0000000000001101Test; Neurology Neuroimmunollogy & Neuroinflammation 2021 Jan 10;9(1):e1101; https://uvadoc.uva.es/handle/10324/64718Test; Neurology Neuroimmunology & Neuroinflammation |
| DOI: | 10.1212/NXI.0000000000001101 |
| الإتاحة: | https://doi.org/10.1212/NXI.0000000000001101Test https://uvadoc.uva.es/handle/10324/64718Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.9C1E434F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23327812 |
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| DOI: | 10.1212/NXI.0000000000001101 |