دورية أكاديمية
Intensity modulated arc therapy implementation in a three phase adaptive (18)F-FDG-PET voxel intensity-based planning strategy for head-and-neck cancer
| العنوان: | Intensity modulated arc therapy implementation in a three phase adaptive (18)F-FDG-PET voxel intensity-based planning strategy for head-and-neck cancer |
|---|---|
| المؤلفون: | Berwouts, Dieter, Olteanu, Luiza Ana Maria, Speleers, Bruno, Duprez, Frédéric, Madani, Indira, Vercauteren, Tom, De Neve, Wilfried, De Gersem, Werner |
| المصدر: | Berwouts, Dieter; Olteanu, Luiza Ana Maria; Speleers, Bruno; Duprez, Frédéric; Madani, Indira; Vercauteren, Tom; De Neve, Wilfried; De Gersem, Werner (2016). Intensity modulated arc therapy implementation in a three phase adaptive (18)F-FDG-PET voxel intensity-based planning strategy for head-and-neck cancer. Radiation Oncology, 11:52. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2016 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Clinic for Radiation Oncology, 610 Medicine & health |
| الوصف: | BACKGROUND This study investigates the implementation of a new intensity modulated arc therapy (IMAT) class solution in comparison to a 6-static beam step-and-shoot intensity modulated radiotherapy (s-IMRT) for three-phase adaptive (18)F-FDG-PET-voxel-based dose-painting-by-numbers (DPBN) for head-and-neck cancer. METHODS We developed (18)F-FDG-PET-voxel intensity-based IMAT employing multiple arcs and compared it to clinically used s-IMRT DPBN. Three IMAT plans using (18)F-FDG-PET/CT acquired before treatment (phase I), after 8 fractions (phase II) and CT acquired after 18 fractions (phase III) were generated for each of 10 patients treated with 3 s-IMRT plans based on the same image sets. Based on deformable image registration (ABAS, version 0.41, Elekta CMS Software, Maryland Heights, MO), doses of the 3 plans were summed on the pretreatment CT using validated in-house developed software. Dosimetric indices in targets and organs-at-risk (OARs), biologic conformity of treatment plans set at ≤5 %, treatment quality and efficiency were compared between IMAT and s-IMRT for the whole group and for individual patients. RESULTS Doses to most organs-at-risk (OARs) were significantly better in IMAT plans, while target levels were similar for both types of plans. On average, IMAT ipsilateral and contralateral parotid mean doses were 14.0 % (p = 0.001) and 12.7 % (p < 0.001) lower, respectively. Pharyngeal constrictors D50% levels were similar or reduced with up to 54.9 % for IMAT compared to s-IMRT for individual patient cases. IMAT significantly improved biologic conformity by 2.1 % for treatment phases I and II. 3D phantom measurements reported an agreement of ≥95 % for 3 % and 3 mm criteria for both treatment modalities. IMAT delivery time was significantly shortened on average by 41.1 %. CONCLUSIONS IMAT implementation significantly improved the biologic conformity as compared to s-IMRT in adaptive dose-escalated DPBN treatments. The better OAR sparing and faster delivery highly improved the treatment efficiency. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1748-717X |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/130486/1/Intensity.pdfTest; info:pmid/27039294; urn:issn:1748-717X |
| DOI: | 10.5167/uzh-130486 |
| DOI: | 10.1186/s13014-016-0629-3 |
| الإتاحة: | https://doi.org/10.5167/uzh-13048610.1186/s13014-016-0629-3Test https://www.zora.uzh.ch/id/eprint/130486Test/ https://www.zora.uzh.ch/id/eprint/130486/1/Intensity.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.9BCA4925 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1748717X |
|---|---|
| DOI: | 10.5167/uzh-130486 |