دورية أكاديمية
Clinical Evaluation of Gamma Knife Stereotactic Radiosurgery for Metastatic Disease in Elderly Patients
| العنوان: | Clinical Evaluation of Gamma Knife Stereotactic Radiosurgery for Metastatic Disease in Elderly Patients |
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| المؤلفون: | Bishr, Mai, Tancu, Cornel, Fersht, Naomi, Kitchen, Neil, Kosmin, Michael |
| المصدر: | Neuro-Oncology ; volume 24, issue Supplement_4, page iv9-iv10 ; ISSN 1522-8517 1523-5866 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Neurology (clinical), Oncology |
| الوصف: | AIMS Gamma Knife Stereotactic Radiosurgery (GK-SRS) is an effective treatment option for limited brain metastases (BM); however, there is a paucity of data about its use in the elderly. Our aim is to explore the clinical outcomes of elderly cancer patients treated for BM with GK-SRS at our institution. METHOD We identified cancer patients aged ≥80 years at the time of receiving GK-SRS to BM between July 2017 and August 2021 from our electronic institutional database. Descriptive statistics and Kaplan–Meier analysis were performed using SPSS v.22. RESULTS A total of 24 patients were identified, with a median age of 83 years (range 80.1-89.9). The most common primary tumours were melanoma (58.4%) and lung (20.8%). In 14 patients (58%), multiple BM were treated simultaneously with a median of 2 lesions (range 2-15). The median target volume was 1.34cc (range 0.03-15.06). Prescribed doses ranged from 18Gy – 25Gy, prescribed to the 41-97% isodose line. After a median follow-up of 6.9 months (range 1.9-49.4 months), the local control rate (LCR) was 91.3% and the median post-GK-SRS overall survival was 9.8 months (95%CI 5.4-14.3). This compares to our previously published data from our wider GK-SRS-treated BM patient cohort, which showed a median survival of 15.6 months and LCR of 94.6%. CONCLUSION GK-SRS is an effective treatment modality for selected cancer patients with BM, including those over 80 years of age. Multi-institutional prospective studies are warranted to further explore the safety and functional outcomes of GK-SRS in elderly cancer patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/neuonc/noac200.042 |
| الإتاحة: | https://doi.org/10.1093/neuonc/noac200.042Test https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_4/iv9/46176075/noac200.042.pdfTest |
| حقوق: | https://academic.oup.com/pages/standard-publication-reuse-rightsTest |
| رقم الانضمام: | edsbas.9BA3373 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/neuonc/noac200.042 |
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