دورية أكاديمية
Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type
| العنوان: | Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type |
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| المؤلفون: | Sleurs, D., Speranza, M., Etain, B., Aouizerate, B., Aubin, V., Bellivier, F., Belzeaux, R., Carminati, M., Courtet, P., Dubertret, C., Fredembach, B., Haffen, E., Groppi, F., Laurent, P., Leboyer, M., Llorca, P., Olié, E., Polosan, M., Schwan, Raymund, Weill, D., Passerieux, C., Roux, P. |
| المساهمون: | Fondation FondaMental Créteil, Hôpital Louis Mourier - AP-HP Colombes, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Hospitalier de Versailles André Mignot (CHV), GHU AP-HP Nord - Université Paris Cité, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S 1144 / U1144)), Hôpital Lariboisière-Fernand-Widal APHP, Centre hospitalier Charles Perrens Bordeaux, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Princesse Grace, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), GIN Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie Créteil (FHU ADAPT), CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Centre Psychothérapique de Nancy Laxou (CPN), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), This study was supported by a grant from the Centre Hospitalier de Versailles (Bourse Registre 2019), the Fondation FondaMental, Créteil, France, and the Investissements d’Avenir Programs managed by the ANR under references ANR-11-IDEX-0004–02 and ANR-10-COHO-10–01., ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010) |
| المصدر: | ISSN: 1018-8827. |
| بيانات النشر: | HAL CCSD Springer Verlag (Germany) |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Bipolar disorder, Cognition, Early onset, Functioning, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Defining homogeneous subgroups of bipolar disorder (BD) is a major goal in personalized psychiatry and research. According to the neurodevelopmental theory, age at onset may be a key variable. As potential trait markers of neurodevelopment, cognitive and functional impairment should be greater in the early form of the disease, particularly type 1 BD (BD I). The age at onset was assessed in a multicenter, observational sample of 4190 outpatients with BD. We used a battery of neuropsychological tests to assess six domains of cognition. Functioning was measured using the Functioning Assessment Short Test (FAST). We studied the potential moderation of the type of BD on the associations between the age at onset and cognitive and functioning in a subsample of 2072 euthymic participants, controlling for potential clinical and socio-demographic covariates. Multivariable analyses showed cognition to not be impaired in individuals with early (21-30 years) and very early-life (before 14 years) onset of BD. Functioning was equivalent between individuals with early and midlife-onset of BD II and NOS but better for individuals with early onset of BD I. In contrast, functioning was not worse in individuals with very early-onset BD I but worse in those with very early-onset BD II and NOS. Early-life onset BDs were not characterized by poorer cognition and functioning. Our results do not support the neurodevelopmental view that a worse cognitive prognosis characterizes early-life onset BD. This study suggests that functional remediation may be prioritized for individuals with midlife-onset BD I and very early life onset BD 2 and NOS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38702455; hal-04573257; https://hal.science/hal-04573257Test; PUBMED: 38702455; WOS: 001214761100002 |
| DOI: | 10.1007/s00787-024-02372-3 |
| الإتاحة: | https://doi.org/10.1007/s00787-024-02372-3Test https://hal.science/hal-04573257Test |
| رقم الانضمام: | edsbas.9B9BBCD0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00787-024-02372-3 |
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