دورية أكاديمية
Dissecting abdominal aortic aneurysm is aggravated by genetic inactivation of LIGHT (TNFSF14)
| العنوان: | Dissecting abdominal aortic aneurysm is aggravated by genetic inactivation of LIGHT (TNFSF14) |
|---|---|
| المؤلفون: | Herrero-Cervera, Andrea, Piqueras Ruiz, Laura, Martín Vañó, Susana, Taberner Cortés, Alida, Aguilar Ballester, María, Vinué Visús, María Ángela, Espinós Estévez, Carla, Martínez Hervás, Sergio, González Navarro, Herminia |
| المصدر: | Herrero-Cervera, Andrea Piqueras Ruiz, Laura Martín Vañó, Susana Taberner Cortés, Alida Aguilar Ballester, María Vinué Visús, María Ángela Espinós Estévez, Carla Martínez Hervás, Sergio González Navarro, Herminia 2021 Dissecting abdominal aortic aneurysm is aggravated by genetic inactivation of LIGHT (TNFSF14) Biomedicines 9 11 1 17 |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Universitat de València: Roderic - Repositorio de contenido libre |
| مصطلحات موضوعية: | medicina, bioquímica clínica, farmacologia |
| الوصف: | Abdominal aortic aneurysm (AAA), is a complex disorder characterized by vascular vessel wall remodeling. LIGHT (TNFSF14) is a proinflammatory cytokine associated with vascular disease. In the present study, the impact of genetic inactivation of Light was investigated in dissecting AAA induced by angiotensin II (AngII) in the Apolipoprotein E-deficient (Apoe−/−) mice. Studies in aortic human (ah) vascular smooth muscle cells (VSMC) to study potential translation to human pathology were also performed. AngII-treated Apoe−/−Light−/− mice displayed increased abdominal aorta maximum diameter and AAA severity compared with Apoe−/− mice. Notably, reduced smooth muscle α-actin+ area and Acta2 and Col1a1 gene expression were observed in AAA from Apoe−/−Light−/− mice, suggesting a loss of VSMC contractile phenotype compared with controls. Decreased Opn and augmented Sox9 expression, which are associated with detrimental and non-contractile osteochondrogenic VSMC phenotypes, were also seen in AngII-treated Apoe−/−Light−/− mouse AAA. Consistent with a role of LIGHT preserving VSMC contractile characteristics, LIGHT-treatment of ahVSMCs diminished the expression of SOX9 and of the pluripotency marker CKIT. These effects were partly mediated through lymphotoxin β receptor (LTβR) as the silencing of its gene ablated LIGHT effects on ahVSMCs. These studies suggest a protective role of LIGHT through mechanisms that prevent VSMC trans-differentiation in an LTβR-dependent manner. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2227-9059 |
| العلاقة: | Biomedicines, 2021, vol. 9, num. 11, p. 1-17; Herrero-Cervera, A., Espinós-Estévez, C., Martín-Vañó, S., Taberner-Cortés, A., Aguilar-Ballester, M., Vinué, Á., Piqueras, L., Martínez-Hervás, S., & González-Navarro, H. (2021). Dissecting Abdominal Aortic Aneurysm Is Aggravated by Genetic Inactivation of LIGHT (TNFSF14). En Biomedicines (Vol. 9, Issue 11, p. 1518). MDPI AG. https://doi.org/10.3390/biomedicines9111518Test; https://hdl.handle.net/10550/93564Test; 149198 |
| DOI: | 10.3390/biomedicines9111518 |
| الإتاحة: | https://doi.org/10.3390/biomedicines9111518Test https://hdl.handle.net/10550/93564Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.9B88038B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22279059 |
|---|---|
| DOI: | 10.3390/biomedicines9111518 |