دورية أكاديمية
Head and neck and esophageal cancers after liver transplant: Results from a multicenter cohort study. Italy, 1997-2010
| العنوان: | Head and neck and esophageal cancers after liver transplant: Results from a multicenter cohort study. Italy, 1997-2010 |
|---|---|
| المؤلفون: | Piselli P., Burra P., Lauro A., Baccarani U., Ettorre G. M., Vizzini G. B., Rendina M., Rossi M., Tisone G., Zamboni F., Bortoluzzi I., Pinna A. D., Risaliti A., Galatioto L., Vennarecci G., Di Leo A., Nudo F., Sforza D., Fantola G., Cimaglia C., Verdirosi D., Virdone S., Serraino D. |
| المساهمون: | Piselli, P., Burra, P., Lauro, A., Baccarani, U., Ettorre, G. M., Vizzini, G. B., Rendina, M., Rossi, M., Tisone, G., Zamboni, F., Bortoluzzi, I., Pinna, A. D., Risaliti, A., Galatioto, L., Vennarecci, G., Di Leo, A., Nudo, F., Sforza, D., Fantola, G., Cimaglia, C., Verdirosi, D., Virdone, S., Serraino, D. |
| سنة النشر: | 2015 |
| المجموعة: | Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| مصطلحات موضوعية: | aerodigestive cancer, cancer risk, immunosuppression, liver cirrhosi, liver disease, oncogenic viruse, organ transplantation, Adult, Aged, 80 and over, Esophageal Neoplasm, Female, Head and Neck Neoplasm, Human, Incidence, Italy, Kaplan-Meier Estimate, Male, Middle Aged, Risk Factor, Liver Transplantation, Postoperative Complications |
| الوصف: | This study quantified the risk of head and neck (HN) and esophageal cancers in 2770 Italian liver transplant (LT) recipients. A total of 186 post-transplant cancers were diagnosedincluding 32 cases of HN cancers and nine cases of esophageal carcinoma. The 10-year cumulative risk for HN and esophageal carcinoma was 2.59%. Overall, HN cancers were nearly fivefold more frequent in LT recipients than expected (standardized incidence ratios - SIR=4.7, 95% CI: 3.2-6.6), while esophageal carcinoma was ninefold more frequent (SIR=9.1, 95% CI: 4.1-17.2). SIRs ranged from 11.8 in LT with alcoholic liver disease (ALD) to 1.8 for LT without ALD for HN cancers, and from 23.7 to 2.9, respectively, for esophageal carcinoma. Particularly elevated SIRs in LT with ALD were noted for carcinomas of tongue (23.0) or larynx (13.7). Our findings confirmed and quantified the large cancer excess risk in LT recipients with ALD. The risk magnitude and the prevalence of ALD herein documented stress the need of timely and specifically organized programs for the early diagnosis of cancer among LT recipients, particularly for high-risk recipients like those with ALD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25778395; info:eu-repo/semantics/altIdentifier/wos/WOS:000356007100010; volume:28; issue:7; firstpage:841; lastpage:848; numberofpages:8; journal:TRANSPLANT INTERNATIONAL; http://hdl.handle.net/11586/246242Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84930472933; https://onlinelibrary.wiley.com/journal/14322277Test |
| DOI: | 10.1111/tri.12555 |
| الإتاحة: | https://doi.org/10.1111/tri.12555Test http://hdl.handle.net/11586/246242Test https://onlinelibrary.wiley.com/journal/14322277Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9AE7BD13 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/tri.12555 |
|---|