دورية أكاديمية
Relationship between risk factors and mortality in type 1 diabetic patients in europe: The eurodiab prospective complications study (PCS)
| العنوان: | Relationship between risk factors and mortality in type 1 diabetic patients in europe: The eurodiab prospective complications study (PCS) |
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| المؤلفون: | Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H. Karamanos B, Kofinis A, Petrou K, GIORGINO, Francesco, Picca G, Angarano A, De Pergola G, LAVIOLA, Luigi, Giorgino R, Songini M, Casu A, Pedron M, Pintus S, Fossarello M, Ferriss JB, Grealy G, Keefe DO, Toeller M, Arden C, Rottiers R, Tuyttens C, Priem H, Ebeling P, Kylliäinen M, Koivisto VA, Idzior Walus B, Sieradzki J, Cyganek K, Lemkes HH, Lemkes Stuffken JC, Nunes Correa J, Rogado MC, Gardete Correia L, Cardoso MC, Silva A, Boavida J, Sa Marques MM, Michel G, Wirion R, Cardillo S, Pozza G, Mangili R, Asnaghi V, Standl E, Schaffler B, Brand H, Harms A, Soussan B, Verier Mine O, Fallas P, Fallas MC, Fuller JH, Holloway J, Asbury L, Betteridge DJ, Cathelineau G, Bouallouche A, Cathelineau BV, Santeusanio F, Rosi G, D'Alessandro V, Cagini C, Bottini P, Reboldi P, Navalesi R, Penno G, Bandinelli S, Miccoli R, Nannipieri M, Ghirlanda G, Saponara C, Cotroneo P, Manto A, Minnella A, Ward JD, Tesfaye S, Eaton S, Mody C, Borra M, Perin PC, Giunti S, Grassi G, Pagano GF, Porta M, Sivieri R, Vitelli F, Ferrari D, Papazoglou N, Manes G, Muggeo M, Iagulli M, Irsigler K, Abrahamian H, Walford S, Sinclair J, Hughes S, McLelland V, Ward J, Roglic G, Metelko Z, Pepeonik ZR, Babic Z, Ionescu Tirgoviste C, Coszma A, Guja C, Karamanos B, Sjolie AK, Chaturvedi B, Ferriss B, Chaturvedi N, Webb D, Shipley M, Livingstone SJ, Viberti GC, Swaminathan R, Lumb P, Collins A, Sankaralingham S, Crook M.A. |
| المساهمون: | Soedamah Muthu, Sabita S., Chaturvedi, Nish, Witte, Daniel R., Stevens, Lynda K., Porta, Massimo, Fuller, John H., Karamanos B, Kofinis, A, Petrou, K, Giorgino, Francesco, Picca, G, Angarano, A, De Pergola, G, Laviola, Luigi, Giorgino, R, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, M, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, Idzior Walus, B, Sieradzki, J, Cyganek, K, Lemkes, Hh, Lemkes Stuffken, Jc, Nunes Correa, J, Rogado, Mc, Gardete Correia, L, Cardoso, Mc, Silva, A, Boavida, J, Sa Marques, Mm, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, Soussan, B, Verier Mine, O, Fallas, P, Fallas, Mc, Fuller, Jh, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, Cathelineau, Bv, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, P, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, Perin, Pc, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Ferrari, D, Papazoglou, N, Manes, G, Muggeo, M, Iagulli, M, Irsigler, K, Abrahamian, H, Walford, S |
| سنة النشر: | 2008 |
| المجموعة: | Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| مصطلحات موضوعية: | Adolescent, Adult, Albuminuria, Cohort Studie, Diabetes Mellitus, Type 1, Diabetic Neuropathie, Diabetic Retinopathy, Europe, Female, Human, Hypotension, Orthostatic, Male, Middle Aged, Proportional Hazards Model, Risk Factor, Internal Medicine, Endocrinology, Diabetes and Metabolism, Advanced and Specialized Nursing |
| الوصف: | OBJECTIVE: The purpose of this study was to examine risk factors for mortality in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: Baseline risk factors were measured in the EURODIAB Prospective Cohort Study with 2,787 type 1 diabetic patients (51% men and 49% women) recruited from 16 European countries. Mortality data were collected during a 7-year follow-up. RESULTS: There was an annual mortality rate of 5 per 1,000 person-years in patients with type 1 diabetes (mean age at baseline 33 years, range 15-61 years); of the total 2,787 subjects, 102 died. The final multivariable model contained age at baseline (standardized hazard ratio 1.78 [95% CI 1.44-2.20]), A1C (1.18 [0.95-1.46]), waist-to-hip ratio (WHR) (1.32 [1.14-1.52]), pulse pressure (1.33 [1.13-1.58]), and non-HDL cholesterol (1.33 [1.12-1.60]) as risk factors for all-cause mortality. Macroalbuminuria (2.39 [1.19-4.78]) and peripheral (1.88 [1.06-3.35]) and autonomic neuropathy (2.40 [1.32-4.36]) were the most important risk markers for mortality. Similar risk factors were found for all-cause, non-cardiovascular disease (CVD), unknown-cause, and CVD mortality. CONCLUSIONS: Important risk factors for the increased total and non-CVD mortality in type 1 diabetic patients are age, WHR, pulse pressure, and non-HDL cholesterol. Microvascular complications from macroalbuminuria and peripheral and autonomic neuropathy are strong risk markers for future mortality exceeding the effect of the traditional risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000257421000017; volume:31; issue:7; firstpage:1360; lastpage:1366; numberofpages:7; journal:DIABETES CARE; http://hdl.handle.net/11586/198842Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-49649102891; http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test |
| DOI: | 10.2337/dc08-0107 |
| الإتاحة: | https://doi.org/10.2337/dc08-0107Test http://hdl.handle.net/11586/198842Test http://care.diabetesjournals.org/cgi/reprint/31/7/1360Test |
| رقم الانضمام: | edsbas.9ABF9E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/dc08-0107 |
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