دورية أكاديمية
The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT)
| العنوان: | The statistical analysis plan for the unification of treatments and interventions for tinnitus patients randomized clinical trial (UNITI-RCT) |
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| المؤلفون: | Simoes, Jorge Piano, Schoisswohl, Stefan, Schlee, Winfried, Basso, Laura, Bernal-Robledano, Alberto, Boecking, Benjamin, Cima, Rilana, Denys, Sam, Engelke, Milena, Escalera-Balsera, Alba, Gallego-Martinez, Alvaro, Gallus, Silvano, Kikidis, Dimitris, Lopez-Escamez, Jose A. A., Marcrum, Steven C. C., Markatos, Nikolaos, Martin-Lagos, Juan, Martinez-Martinez, Marta, Mazurek, Birgit, Vassou, Evgenia, Jarach, Carlotta Micaela, Mueller-Locatelli, Nicolas, Neff, Patrick, Niemann, Uli, Omar, Hafez Kader, Puga, Clara, Schleicher, Miro, Unnikrishnan, Vishnu, Perez-Carpena, Patricia, Pryss, Ruediger, Robles-Bolivar, Paula, Rose, Matthias, Schecklmann, Martin, Schiele, Tabea, Schobel, Johannes, Spiliopoulou, Myra, Stark, Sabine, Vogel, Carsten, Wunder, Nina, Zachou, Zoi, Langguth, Berthold |
| المصدر: | Simoes , J P , Schoisswohl , S , Schlee , W , Basso , L , Bernal-Robledano , A , Boecking , B , Cima , R , Denys , S , Engelke , M , Escalera-Balsera , A , Gallego-Martinez , A , Gallus , S , Kikidis , D , Lopez-Escamez , J A A , Marcrum , S C C , Markatos , N , Martin-Lagos , J , Martinez-Martinez , M , Mazurek , B , Vassou , E , Jarach , C M , Mueller-Locatelli , N , Neff , P , Niemann .... |
| سنة النشر: | 2023 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | PACKAGE |
| الوصف: | Background: Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potentially increased effectiveness of a combination of treatments and personalized treatments for each tinnitus patient. Methods: Within the Unification of Treatments and Interventions for Tinnitus Patients project, a multicenter, randomized clinical trial is conducted with the aim to compare the effectiveness of single treatments and combined treatments on tinnitus distress (UNITI-RCT). Five different tinnitus centers across Europe aim to treat chronic tinnitus patients with either cognitive behavioral therapy, sound therapy, structured counseling, or hearing aids alone, or with a combination of two of these treatments, resulting in four treatment arms with single treatment and six treatment arms with combinational treatment. This statistical analysis plan describes the statistical methods to be deployed in the UNITI-RCT. Discussion: The UNITI-RCT trial will provide important evidence about whether a combination of treatments is superior to a single treatment alone in the management of chronic tinnitus patients. This pre-specified statistical analysis plan details the methodology for the analysis of the UNITI trial results. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/053b3619-f059-4a31-828f-46db54276624Test |
| DOI: | 10.1186/s13063-023-07303-2 |
| الإتاحة: | https://doi.org/10.1186/s13063-023-07303-2Test https://cris.maastrichtuniversity.nl/en/publications/053b3619-f059-4a31-828f-46db54276624Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9A89EDE6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s13063-023-07303-2 |
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