دورية أكاديمية
Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions
| العنوان: | Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions |
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| المؤلفون: | Couvineau, Alain, Voisin, Thierry, Nicole, Pascal, Gratio, Valerie, Blais, Anne |
| المساهمون: | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 1007-9327 ; World Journal of Gastroenterology ; https://agroparistech.hal.science/hal-04355985Test ; World Journal of Gastroenterology, 2021, 27, pp.7582 - 7596. ⟨10.3748/wjg.v27.i44.7582⟩. |
| بيانات النشر: | HAL CCSD Baishideng Publishing Group Co. Limited |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Alain Couvineau 0000-0003-2912-5168 Thierry Voisin 0000-0002-4320-5183 Pascal Nicole 0000-0002-0004-616X Valerie Gratio 0000-0001-8563-3293 Anne Blais 0000-0002-0897-7612 Invited article Externally peer reviewed Peer-review report's scientific quality classification Grade A (Excellent): 0 Grade B (Very good): 0 Orexin Neuropeptide G-protein coupled receptor superfamily Inflammation Metabolic syndrome Cancer, Alain Couvineau 0000-0003-2912-5168, Thierry Voisin 0000-0002-4320-5183, Pascal Nicole 0000-0002-0004-616X, Valerie Gratio 0000-0001-8563-3293, Anne Blais 0000-0002-0897-7612 Invited article, Externally peer reviewed Peer-review report's scientific quality classification Grade A (Excellent): 0 Grade B (Very good): 0 Orexin, Neuropeptide, G-protein coupled receptor superfamily, Inflammation, Metabolic syndrome, Cancer, [SDV]Life Sciences [q-bio] |
| الوصف: | Hypothalamic neuropeptides named hypocretin/orexins which were identified in 1998 regulate critical functions such as wakefulness in the central nervous system. These past 20 years had revealed that orexins/receptors system was also present in the peripheral nervous system where they participated to the regulation of multiple functions including blood pressure regulation, intestinal motility, hormone secretion, lipolyze and reproduction functions. Associated to these peripheral functions, it was found that orexins and their receptors were involved in various diseases such as acute/chronic inflammation, metabolic syndrome and cancers. The present review suggests that orexins or the orexin neural circuitry represent potential therapeutic targets for the treatment of multiple pathologies related to inflammation including intestinal bowel disease, multiple sclerosis and septic shock, obesity and digestive cancers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04355985; https://agroparistech.hal.science/hal-04355985Test; https://agroparistech.hal.science/hal-04355985/documentTest; https://agroparistech.hal.science/hal-04355985/file/Orexins%20A%20promising%20target%20to%20digestive%20cancers,%20inflammation,.pdfTest |
| DOI: | 10.3748/wjg.v27.i44.7582 |
| الإتاحة: | https://doi.org/10.3748/wjg.v27.i44.7582Test https://agroparistech.hal.science/hal-04355985Test https://agroparistech.hal.science/hal-04355985/documentTest https://agroparistech.hal.science/hal-04355985/file/Orexins%20A%20promising%20target%20to%20digestive%20cancers,%20inflammation,.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.9A0C7AC1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3748/wjg.v27.i44.7582 |
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