دورية أكاديمية
Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth
| العنوان: | Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth |
|---|---|
| المؤلفون: | Mullard, Mathilde, Cadé, Marie, Morice, Sarah, Dupuy, Maryne, Danieau, Geoffroy, Amiaud, Jérome, Renault, Sarah, Lézot, Frédéric, Brion, Régis, Thepault, Rose, Anne, Ory, Benjamin, Lamoureux, François, Corre, Isabelle, Brounais-Leroyer, Bénédicte, Rédini, Françoise, Verrecchia, Franck |
| المساهمون: | Sarcomes osseux et remodelage des tissus calcifiés - INSERM U1238 (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, Hôtel-Dieu de Nantes |
| المصدر: | ISSN: 2072-6694. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | GANT61, Gli1, SHH, ewing’s sarcoma, osteosarcoma, primary tumor growth, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Osteosarcoma (OS) and Ewing’s sarcoma (ES) are the most common malignant bone tumors in children and adolescents. In many cases, the prognosis remains very poor. The Sonic hedgehog (SHH) signaling pathway, strongly involved in the development of many cancers, regulate transcription via the transcriptional factors Gli1-3. In this context, RNAseq analysis of OS and ES cell lines reveals an increase of some major compounds of the SHH signaling cascade in ES cells, such as the transcriptional factor Gli1. This increase leads to an augmentation of the transcriptional response of Gli1 in ES cell lines, demonstrating a dysregulation of Gli1 signaling in ES cells and thus the rationale for targeting Gli1 in ES. The use of a preclinical model of ES demonstrates that GANT61, an inhibitor of the transcriptional factor Gli1, reduces ES primary tumor growth. In vitro experiments show that GANT61 decreases the viability of ES cell, mainly through its ability to induce caspase-3/7-dependent cell apoptosis. Taken together, these results demonstrates that GANT61 may be a promising therapeutic strategy for inhibiting the progression of primary ES tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33228057; inserm-04090341; https://inserm.hal.science/inserm-04090341Test; https://inserm.hal.science/inserm-04090341/documentTest; https://inserm.hal.science/inserm-04090341/file/cancers-12-03438-v2.pdfTest; PUBMED: 33228057; PUBMEDCENTRAL: PMC7699338; WOS: 000592949200001 |
| DOI: | 10.3390/cancers12113438 |
| الإتاحة: | https://doi.org/10.3390/cancers12113438Test https://inserm.hal.science/inserm-04090341Test https://inserm.hal.science/inserm-04090341/documentTest https://inserm.hal.science/inserm-04090341/file/cancers-12-03438-v2.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.99C66C47 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers12113438 |
|---|