دورية أكاديمية
Levels of Adipokines in Amniotic Fluid and Cord Blood Collected from Dichorionic-Diamniotic Twins Discordant for Fetal Growth
| العنوان: | Levels of Adipokines in Amniotic Fluid and Cord Blood Collected from Dichorionic-Diamniotic Twins Discordant for Fetal Growth |
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| المساهمون: | College of Medicine, Dept. of Obstetrics & Gynecology, Seung Mi Lee, Joong Shin Park, Errol R. Norwitz, Sitthysack Panyavatthanasinh, Sun Min Kim, JoonHo Lee, Chan-Wook Park, Byoung Jae Kim, Jong Kwan Jun, Lee, Joon Ho |
| بيانات النشر: | Public Library of Science United States |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adipokines/analysis, Adipokines/blood, Adipokines/metabolism, Amniocentesis, Amniotic Fluid/metabolism, Birth Weight/physiology, Female, Fetal Blood/metabolism, Fetal Development/physiology, Humans, Leptin/analysis, Leptin/blood, Leptin/metabolism, Plasminogen Activator Inhibitor 1/analysis, Plasminogen Activator Inhibitor 1/blood, Plasminogen Activator Inhibitor 1/metabolism, Pregnancy, Pregnancy Trimesters, Retrospective Studies, Twins, Dizygotic |
| الوصف: | OBJECTIVE: To compare the concentrations of adipokines in amniotic fluid (AF) and cord blood collected from discordant dichorionic-diamniotic (DCDA) twin fetuses. STUDY DESIGN: The study population included DCDA twins discordant for fetal growth (birth weight difference >10%) who either underwent mid-trimester amniocentesis for routine clinical indication (Cohort 1) or whose amniotic fluid was collected at the time of delivery (Cohort 2). In both cohorts, cord blood was collected at delivery. RESULTS: A total of 92 twin pairs were enrolled (n = 49 in Cohort 1; n = 43 in Cohort 2). In Cohort 1, the concentrations of adiponectin (median, 68.5 ng/mL vs 61.4 ng/mL; p<0.05) and leptin (median, 13.9 ng/mL vs 11.2 ng/mL; p<0.1) in mid-trimester AF were significantly higher in smaller compared with larger twins. In Cohort 2, the concentration of serpin E1 (median, 246.0 ng/mL vs 182.8 ng/mL; p<0.01) in AF at delivery was significantly higher in smaller twins, but no difference was noted in adiponectin and leptin concentrations. Levels of adiponectin (median, 10425.5 ng/mL vs 11552.0 ng/mL; p<0.005) and leptin (median, 2.1 ng/mL vs 2.6 ng/mL; p<0.005) were significantly lower in the cord blood of smaller twins whereas cord blood concentrations of serpin E1 (median, 15.5 ng/mL vs 13.3 ng/mL; p<0.05) was higher in the smaller twins. CONCLUSION: In discordant DCDA twin pairs, concentrations of adiponectin, leptin, and serpin E1 in mid-trimester AF, AF at delivery, and cord blood at birth vary significantly but predictably between the smaller and larger twins. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | PLOS ONE; J02540; OAK-2016-04231; https://ir.ymlib.yonsei.ac.kr/handle/22282913/151745Test; T201602664; PLOS ONE, Vol.11(5) : e0154537, 2016 |
| DOI: | 10.1371/journal.pone.0154537 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0154537Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/151745Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.9980E233 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0154537 |