التفاصيل البيبلوغرافية
| العنوان: |
Superior neutralizing response after first versus second SARS‐CoV‐2 infection in fully vaccinated individuals |
| المؤلفون: |
Rivas, Gonzalo, Labiod, Nuria, Luczkowiak, Joanna, Lasala, Fátima, Rolo, Marta, Mancheño‐Losa, Mikel, Rial‐Crestelo, David, Lora‐Tamayo, Jaime, Pérez‐Rivilla, Alfredo, Folgueira, María Dolores, Delgado, Rafael |
| المصدر: |
Journal of Medical Virology ; volume 95, issue 11 ; ISSN 0146-6615 1096-9071 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Currently, the majority of the population has been vaccinated against COVID‐19 and/or has experienced SARS‐CoV‐2 infection either before or after vaccination. The immunological response to repeated episodes of infections is not completely clear. We measured SARS‐CoV‐2 specific neutralization titers by a pseudovirus assay after BA.1 infection and RBD‐specific immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin M (IgM) in a cohort of COVID‐19 uninfected and triple vaccinated individuals (breakthrough infection group, BTI) as compared with those previously infected by SARS‐CoV‐2 (reinfection group, REI) who underwent identical vaccination schedule. SARS‐CoV‐2 specific neutralizing response after BA.1 infection was significantly higher in the BTI group as compared with the REI. Furthermore, neutralization titers in REI were not significant different from convalescent non reinfected controls. RBD‐specific IgG and IgA, but not IgM, were also significantly higher in BTI as compared with REI. Our results show that the first episode of SARS‐CoV‐2 infection induces a significant increase in neutralizing titers in triple vaccinated individuals and that previous SARS‐CoV‐2 infection compromise significantly the neutralization response induced by reinfection, even by divergent SARS‐CoV‐2 variants and at least up to 2 years postinfection, suggesting a fundamental limitation in inducing effective booster through the intranasal route in previously infected individuals. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/jmv.29225 |
| الإتاحة: |
https://doi.org/10.1002/jmv.29225Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.99146FE3 |
| قاعدة البيانات: |
BASE |
