دورية أكاديمية
Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke
| العنوان: | Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke |
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| المؤلفون: | De Matteis, Eleonora, De Santis, Federico, Ornello, Raffaele, Censori, Bruno, Puglisi, Valentina, Vinciguerra, Luisa, Giossi, Alessia, Di Viesti, Pietro, Inchingolo, Vincenzo, Fratta, Giovanni Matteo, Diomedi, Marina, Bagnato, Maria Rosaria, Cenciarelli, Silvia, Bedetti, Chiara, Padiglioni, Chiara, Tassinari, Tiziana, Saia, Valentina, Russo, Alessandro, Petruzzellis, Marco, Mezzapesa, Domenico Maria, Caccamo, Martina, Rinaldi, Giuseppe, Bavaro, Alessandra, Paciaroni, Maurizio, Mosconi, Maria Giulia, Foschi, Matteo, Querzani, Pietro, Muscia, Francesco, Gallo Cassarino, Serena, Candelaresi, Paolo, De Mase, Antonio, Guarino, Maria, Cupini, Letizia Maria, Sanzaro, Enzo, Zini, Andrea, La Spada, Salvatore, Palmieri, Carmela, Sepe, Federica Nicoletta, Beretta, Simone, Paci, Cristina, Caggia, Emanuele Alessandro, De Angelis, Maria Vittoria, Bonanni, Laura, Volpi, Gino, Tassi, Rossana, Pistoia, Francesca, Scoditti, Umberto, Tonon, Agnese, Viticchi, Giovanna, Ruzza, Giampietro, Nencini, Patrizia, Cavallini, Anna, Toni, Danilo, Ricci, Stefano, Sacco, Simona |
| المساهمون: | De Matteis, Eleonora, De Santis, Federico, Ornello, Raffaele, Censori, Bruno, Puglisi, Valentina, Vinciguerra, Luisa, Giossi, Alessia, Di Viesti, Pietro, Inchingolo, Vincenzo, Fratta, Giovanni Matteo, Diomedi, Marina, Bagnato, Maria Rosaria, Cenciarelli, Silvia, Bedetti, Chiara, Padiglioni, Chiara, Tassinari, Tiziana, Saia, Valentina, Russo, Alessandro, Petruzzellis, Marco, Mezzapesa, Domenico Maria, Caccamo, Martina, Rinaldi, Giuseppe, Bavaro, Alessandra, Paciaroni, Maurizio, Mosconi, Maria Giulia, Foschi, Matteo, Querzani, Pietro, Muscia, Francesco, Gallo Cassarino, Serena, Candelaresi, Paolo, De Mase, Antonio, Guarino, Maria, Cupini, Letizia Maria, Sanzaro, Enzo, Zini, Andrea, La Spada, Salvatore, Palmieri, Carmela, Sepe, Federica Nicoletta, Beretta, Simone, Paci, Cristina, Caggia, Emanuele Alessandro, De Angelis, Maria Vittoria, Bonanni, Laura, Volpi, Gino, Tassi, Rossana, Pistoia, Francesca, Scoditti, Umberto, Tonon, Agnese, Viticchi, Giovanna, Ruzza, Giampietro, Nencini, Patrizia, Cavallini, Anna, Toni, Danilo, Ricci, Stefano, Sacco, Simona |
| سنة النشر: | 2023 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | aspirin, clopidogrel, follow-up studie, prospective studie, ticagrelor |
| الوصف: | Background: Randomized controlled trials (RCTs) proved that short-term (21-90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient ischemic attack (TIA) without substantially increasing the hemorrhagic risk. We aimed at understanding whether and how real-world use of DAPT differs from RCTs. Methods: READAPT (Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or TIA) is a prospective cohort study including >18-year-old patients treated with DAPT after a noncardioembolic minor ischemic stroke or high-risk TIA from 51 Italian centers. The study comprises a 90-day follow-up from symptom onset. In the present work, we reported descriptive statistics of baseline data of patients recruited up to July 31, 2022, and proportions of patients who would have been excluded from RCTs. We compared categorical data through the χ2 test. Results: We evaluated 1070 patients, who had 72 (interquartile range, 62-79) years median age, were mostly Caucasian (1045; 97.7%), and were men (711; 66.4%). Among the 726 (67.9%) patients with ischemic stroke, 226 (31.1%) did not meet the RCT inclusion criteria because of National Institutes of Health Stroke Scale score >3 and 50 (6.9%) because of National Institutes of Health Stroke Scale score >5. Among the 344 (32.1%) patients with TIA, 69 (19.7%) did not meet the RCT criteria because of age, blood pressure, clinical features, duration of TIA, presence of diabetes score <4 and 252 (74.7%) because of age, blood pressure, clinical features, duration of TIA, presence of diabetes score <6 and no symptomatic arterial stenosis. Additionally, 144 (13.5%) patients would have been excluded because of revascularization procedures. Three hundred forty-five patients (32.2%) did not follow the RCT procedures because of late (>24 hours) DAPT initiation; 776 (72.5%) and 676 (63.2%) patients did not take loading doses of aspirin and clopidogrel, respectively. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36951052; info:eu-repo/semantics/altIdentifier/wos/WOS:001016864400018; volume:54; issue:5; firstpage:1172; lastpage:1181; numberofpages:10; journal:STROKE; https://hdl.handle.net/11573/1695561Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85153803351 |
| DOI: | 10.1161/STROKEAHA.122.041660 |
| الإتاحة: | https://doi.org/10.1161/STROKEAHA.122.041660Test https://hdl.handle.net/11573/1695561Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.98DE785 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/STROKEAHA.122.041660 |
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