مراجعة
What we learned about COVID-19 so far? Notes from underground
| العنوان: | What we learned about COVID-19 so far? Notes from underground |
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| المساهمون: | Uludağ Üniversitesi/Tıp Fakültesi/Alerji ve İmmünoloji Anabilim Dalı., Günaydın, Fatma Esra, HKV-2265-2023, 57210113218 |
| بيانات النشر: | AVES |
| سنة النشر: | 2020 |
| المجموعة: | Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
| مصطلحات موضوعية: | Real-time PCR, Hydroxychloroquine, SARS-CoV-2, Respiratory system, Radiological findings, Clinical features, COVID-19, Angiotensin converting enzyme 2, Arbidol, Bortezomib, C reactive protein, Carfilzomib, Chloroquine, D dimer, Favipiravir, Ferritin, Imatinib, Immunoglobulin G antibody, Immunoglobulin M antibody, Lopinavir plus ritonavir, Remdesivir, Teicoplanin, Adult respiratory distress syndrome, Aerosol, Antihypertensive therapy, Article, Artificial ventilation, Asymptomatic infection, Blood group typing, Bronchoscopy |
| الوصف: | Çalışmada 36 yazar bulunmaktadır. Bu yazarlardan Uludağ Üniversitesi mensuplarının girişleri yapılmıştır. ; The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19. ; Türk Toraks Derneği ; TTS Early Career ... |
| نوع الوثيقة: | review |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2149-2530 |
| العلاقة: | Makale - Uluslararası Hakemli Dergi; Turkish Thoracic Journal; Yurt içi; Sanayi; Günaydın, F. E. vd. (2020). "What we learned about COVID-19 so far? Notes from underground". Turkish Thoracic Journal, 21(3), 185-192.; https://doi.org/10.5152/TurkThoracJ.2020.20052Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/; http://hdl.handle.net/11452/34377Test; 000540904400009; 2-s2.0-85086933171; 185; 192; 21 |
| DOI: | 10.5152/TurkThoracJ.2020.20052 |
| الإتاحة: | https://doi.org/10.5152/TurkThoracJ.2020.20052Test http://hdl.handle.net/11452/34377Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311152Test/ |
| حقوق: | info:eu-repo/semantics/openAccess ; Atıf Gayri Ticari Türetilemez 4.0 Uluslararası ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.98A7B26A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21492530 |
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| DOI: | 10.5152/TurkThoracJ.2020.20052 |