التفاصيل البيبلوغرافية
| العنوان: |
Upregulation of TACE/ADAM17 after Ischemic Preconditioning is Involved in Brain Tolerance |
| المؤلفون: |
Cárdenas, Antonio, Moro, María A., Leza, Juan C., O'Shea, Esther, Dávalos, Antoni, Castillo, José, Lorenzo, Pedro, Lizasoain, Ignacio |
| المصدر: |
Journal of Cerebral Blood Flow & Metabolism ; volume 22, issue 11, page 1297-1302 ; ISSN 0271-678X 1559-7016 |
| بيانات النشر: |
SAGE Publications |
| سنة النشر: |
2002 |
| مصطلحات موضوعية: |
Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| الوصف: |
A short ischemic event (ischemic preconditioning [IPC]) can result in a subsequent resistance to severe ischemic injury (ischemic tolerance [IT]). Although tumor necrosis factor-α (TNF-α) contributes to the brain damage, its expression and neuroprotective role in models of IPC have also been described. However, the role of TNF-α convertase (TACE) in IPC and IT is not known. Using in vitro models, the authors previously demonstrated that TACE is upregulated after ischemic brain damage. In the present study, the authors used a rat model of transient middle cerebral artery occlusion as IPC to investigate TACE expression, its involvement in TNF-α release, and its role in IT. Western blot analysis showed that TACE expression is increased after IPC. Ischemic preconditioning caused TNF-α release, an effect that was blocked by the selective TACE inhibitor BB-1101 (10 mg · kg −1 · day −1 ; SHAM, 1,050 ± 180; IPC, 1,870 ± 290; IPC + BB, 1,320 ± 260 ng/mg; n = 4, P < 0.05). Finally, IPC produced a reduction in infarct volume, which was inhibited by treatment with BB-1101 and with anti–TNF-α (10 μg/5 doses; SHAM + permanent middle cerebral artery occlusion [pMCAO], 335 ± 20; IPC + pMCAO, 244 ± 14; IPC + BB + pMCAO, 300 ± 6; IPC + anti-TNF + pMCAO, 348 ± 22 mm 3 ; n = 6–10, P < 0.05). Taken together, these data demonstrate that TACE is upregulated after IPC, plays a major role in TNF-α shedding in IPC, and has a neuroprotective role in IT. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/01.wcb.0000033968.83623.d0 |
| DOI: |
10.1097/01.WCB.0000033968.83623.D0 |
| الإتاحة: |
https://doi.org/10.1097/01.wcb.0000033968.83623.d0Test |
| حقوق: |
http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest |
| رقم الانضمام: |
edsbas.98878B17 |
| قاعدة البيانات: |
BASE |
