التفاصيل البيبلوغرافية
| العنوان: |
New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes |
| المؤلفون: |
Bender, Christine, Rajendran, Sakthi, von Herrath, Matthias G. |
| المساهمون: |
National Institutes of Health |
| المصدر: |
Frontiers in Endocrinology ; volume 11 ; ISSN 1664-2392 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Endocrinology, Diabetes and Metabolism |
| الوصف: |
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their “attraction” to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fendo.2020.606434 |
| DOI: |
10.3389/fendo.2020.606434/full |
| الإتاحة: |
https://doi.org/10.3389/fendo.2020.606434Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.9847C0F7 |
| قاعدة البيانات: |
BASE |
