كتاب
PARylation, DNA (De)methylation, and Diabetes
| العنوان: | PARylation, DNA (De)methylation, and Diabetes |
|---|---|
| المؤلفون: | Vidaković, Melita, Tolić, Anja, Grdović, Nevena, Ravichandran, Mirunalini, Jurkowski, Tomasz P. |
| المصدر: | Handbook of Nutrition, Diet, and Epigenetics |
| بيانات النشر: | Springer International Publishing |
| سنة النشر: | 2019 |
| المجموعة: | RADaR - Digital Repository of Archived Publications Institute for Biological Research "Sinisa Stankovic" / РАДаР - Репозиторијум Архивираних Дигиталних Радова Институт за биолошка истраживања "Синиша Станковић" |
| مصطلحات موضوعية: | Diabetes, DNA methylation, DNA demethylation, DNMT enzymes, Epigenetic drug targets, Chromatin architecture, PARylation, PARP-1 inhibitors, TET enzymes |
| الوصف: | Diabetes and diabetic complications, autoimmunity and inflammatory diseases, have recently become the focus of epigenetic therapy, since with epigenetic drugs it is possible to reverse aberrant gene expression profiles associated with the disease states. For diabetes, the therapy challenges depend on identifying the most appropriate molecular target and its influence on a relevant gene product. This chapter summarizes the current view on the interplay between ten-eleven translocation (TETs) and the poly(ADP-ribose) polymerase (PARPs) family of enzymes in regulating DNA methylation and how this interplay could be targeted to attenuate diabetes. This molecular interchange jigsaw puzzle is emerging as an important focus of research, and we can expect to see further advances in the elucidation of its role in diabetes as well as other pathologies. Moreover, the possibility for designating specific PARP-1 inhibitors as potential “EPI-drugs” for diabetes prevention/attenuation is also discussed. Understanding the epigenetic machinery and the differential roles of its components is essential for the development of targeted epigenetic therapies for diseases. ; Patel VB, Preedy VR, editors. Handbook of Nutrition, Diet, and Epigenetics. Springer International Publishing; 2019. p. 1857–76. |
| نوع الوثيقة: | book part |
| اللغة: | unknown |
| ردمك: | 978-3-319-55530-0 3-319-55530-8 |
| العلاقة: | https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-55530-0_55Test; https://radar.ibiss.bg.ac.rs/handle/123456789/3616Test; 2-s2.0-85079724776 |
| DOI: | 10.1007/978-3-319-55530-0_55 |
| الإتاحة: | https://doi.org/10.1007/978-3-319-55530-0_55Test https://radar.ibiss.bg.ac.rs/handle/123456789/3616Test |
| حقوق: | restrictedAccess ; ARR ; © Springer Nature Switzerland AG 2019. |
| رقم الانضمام: | edsbas.98446E69 |
| قاعدة البيانات: | BASE |
| ردمك: | 9783319555300 3319555308 |
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| DOI: | 10.1007/978-3-319-55530-0_55 |