دورية أكاديمية
Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation
| العنوان: | Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation |
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| المؤلفون: | Wong, Chi Kin, McLean, Brent A., Baggio, Laurie L., Koehler, Jacqueline A., Hammoud, Rola, Rittig, Nikolaj, Yabut, Julian M., Seeley, Randy J., Brown, Theodore J., Drucker, Daniel J. |
| المصدر: | Wong , C K , McLean , B A , Baggio , L L , Koehler , J A , Hammoud , R , Rittig , N , Yabut , J M , Seeley , R J , Brown , T J & Drucker , D J 2024 , ' Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation ' , Cell Metabolism , vol. 36 , no. 1 , pp. 130-143.e5 . https://doi.org/10.1016/j.cmet.2023.11.009Test |
| سنة النشر: | 2024 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | autonomic nervous system, diabetes, G protein-coupled receptor, glucagon-like peptides, gut-brain axis, immune, inflammation, obesity |
| الوصف: | Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell-mediated gut and systemic inflammation directly through the gut intraepithelial lymphocyte GLP-1R, how GLP-1RAs inhibit systemic inflammation in the absence of widespread immune expression of the GLP-1R remains uncertain. Here, we show that GLP-1R activation attenuates the induction of plasma tumor necrosis factor alpha (TNF-α) by multiple Toll-like receptor agonists. These actions are not mediated by hematopoietic or endothelial GLP-1Rs but require central neuronal GLP-1Rs. In a cecal slurry model of polymicrobial sepsis, GLP-1RAs similarly require neuronal GLP-1Rs to attenuate detrimental responses associated with sepsis, including sickness, hypothermia, systemic inflammation, and lung injury. Mechanistically, GLP-1R activation leads to reduced TNF-α via α 1 -adrenergic, δ-opioid, and κ-opioid receptor signaling. These data extend emerging concepts of brain-immune networks and posit a new gut-brain GLP-1R axis for suppression of peripheral inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/1433066e-7d20-45ef-b620-3948c673bcf3Test |
| DOI: | 10.1016/j.cmet.2023.11.009 |
| الإتاحة: | https://doi.org/10.1016/j.cmet.2023.11.009Test https://pure.au.dk/portal/en/publications/1433066e-7d20-45ef-b620-3948c673bcf3Test http://www.scopus.com/inward/record.url?scp=85181775661&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.97FA1D39 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cmet.2023.11.009 |
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