دورية أكاديمية
Antibiotic Utilization in Hospitalized Children with Bronchiolitis: A Prospective Study Investigating Clinical and Epidemiological Characteristics at a Secondary Hospital in Madrid (2004-2022)
| العنوان: | Antibiotic Utilization in Hospitalized Children with Bronchiolitis: A Prospective Study Investigating Clinical and Epidemiological Characteristics at a Secondary Hospital in Madrid (2004-2022) |
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| المؤلفون: | García-García, María Luz, Alcolea, Sonia, Alonso-López, Patricia, Martín-Martín, Clara, Tena-García, Guadalupe, Casas, Inmaculada, Pozo, Francisco, Méndez-Echevarría, Ana, Hurtado-Gallego, Jara, Calvo, Cristina |
| المساهمون: | Instituto de Salud Carlos III |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute (MDPI) |
| سنة النشر: | 2023 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Antibiotics, Bronchiolitis, Respiratory virus, Respiratory syncytial virus, Human bocavirus, Human adenovirus, Rhinovirus, Chest X-ray |
| الوصف: | Bronchiolitis is a viral respiratory infection, with respiratory syncytial virus (RSV) being the most frequent agent, requiring hospitalization in 1% of affected children. However, there continues to be a noteworthy incidence of antibiotic prescription in this setting, further exacerbating the global issue of antibiotic resistance. This study, conducted at Severo Ochoa Hospital in Madrid, Spain, focused on antibiotic usage in children under 2 years of age who were hospitalized for bronchiolitis between 2004 and 2022. In that time, 5438 children were admitted with acute respiratory infection, and 1715 infants (31.5%) with acute bronchiolitis were included. In total, 1470 (87%) had a positive viral identification (66% RSV, 32% HRV). Initially, antibiotics were prescribed to 13.4% of infants, but this percentage decreased to 7% during the COVID-19 pandemic thanks to adherence to guidelines and the implementation of rapid and precise viral diagnostic methods in the hospital. HBoV- and HAdV-infected children and those with viral coinfections were more likely to receive antibiotics in the univariate analysis. A multivariate logistic regression analysis revealed a statistically independent association between antibiotic prescription and fever > 38 °C (p < 0.001), abnormal chest-X ray (p < 0.001), ICU admission (p = 0.015), and serum CRP (p < 0.001). In conclusion, following guidelines and the availability of rapid and reliable viral diagnostic methods dramatically reduces the unnecessary use of antibiotics in infants with severe bronchiolitis. ; This research was funded by FIS of the Carlos III Institute, grant numbers PI98/0310, PI06/0532, PI12/0129, PI15CIII/00028, PI18CIII/00009, PI21CIII/00019, and PI21/00377. Grant MSD MISP: IISP 60255. ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-0817 |
| العلاقة: | https://doi.org/10.3390/pathogens12121397Test; info:eu-repo/grantAgreement/ES/PI98/0310; info:eu-repo/grantAgreement/ES/PI06/0532; PI12/0129; info:eu-repo/grantAgreement/MINECO//PI12%2F01291/ES/MICROBIOMA VIRAL EN PACIENTES PEDIATRICOS CON INFECCION AGUDA GRAVE DEL TRACTO RESPIRATORIO INFERIOR/; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00377/ES/IMPACTO DE LA PANDEMIA COVID-19 EN LAS INFECCIONES RESPIRATORIAS VIRALES, RESPUSTA INMUNE Y MICROBIOTA EN EL PRIMER AÑO DE VIDA, INCLUYENDO RECIEN NACIDOS PREMATUROS/; info:eu-repo/grantAgreement/ES/PI15CIII/00028; info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2018)/PI18CIII/00009; info:fis/Instituto de Salud Carlos III///PI21-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2021)/PI21CIII/00019; Pathogens. 2023 Nov 28;12(12):1397.; http://hdl.handle.net/20.500.12105/18968Test; Pathogens (Basel, Switzerland) |
| DOI: | 10.3390/pathogens12121397 |
| الإتاحة: | https://doi.org/20.500.12105/18968Test https://doi.org/10.3390/pathogens12121397Test https://hdl.handle.net/20.500.12105/18968Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.97C3F33D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20760817 |
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| DOI: | 10.3390/pathogens12121397 |