دورية أكاديمية
Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics
| العنوان: | Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics |
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| المؤلفون: | Boiarska, Zlata, Pérez-Peña, Helena, Abel, Anne-Catherine, Marzullo, Paola, Álvarez-Bernad, Beatriz, Bonato, Francesca, Santini, Benedetta, Horvath, Dragos, Lucena-Agell, Daniel, Vasile, Francesca, Sironi, Maurizio, Díaz, J Fernando, Prota, Andrea E, Pieraccini, Stefano, Passarella, Daniele |
| المساهمون: | Z. Boiarska, H. Pérez-Peña, A. Abel, P. Marzullo, B. Álvarez-Bernad, F. Bonato, B. Santini, D. Horvath, D. Lucena-Agell, F. Vasile, M. Sironi, J.F. Díaz, A.E. Prota, S. Pieraccini, D. Passarella |
| بيانات النشر: | WILEY-V C H VERLAG GMBH |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | chemical probe, maytansinoid, maytansinol functionalization, microtubule, tubulin, Settore CHIM/06 - Chimica Organica |
| الوصف: | Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36468686; info:eu-repo/semantics/altIdentifier/wos/WOS:000905833100001; volume:29; issue:5; firstpage:1; lastpage:12; numberofpages:12; journal:CHEMISTRY-A EUROPEAN JOURNAL; https://hdl.handle.net/2434/952967Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85145101196 |
| DOI: | 10.1002/chem.202203431 |
| الإتاحة: | https://doi.org/10.1002/chem.202203431Test https://hdl.handle.net/2434/952967Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.97BBBAE5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/chem.202203431 |
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