دورية أكاديمية
Mother-to-child transmission of different HIV-1 subtypes among ARV naive infected pregnant women in Nigeria
| العنوان: | Mother-to-child transmission of different HIV-1 subtypes among ARV naive infected pregnant women in Nigeria |
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| المؤلفون: | Odaibo, G. N., Olaleye, D. O., Heyndrickx, L., Vereecken, K., Houwer, K., Janssens, W. |
| بيانات النشر: | Instituto de Medicina Tropical de São Paulo São Paulo |
| سنة النشر: | 2006 |
| المجموعة: | Institute of Tropical Medicine (ITM): TropMed Central Antwerp |
| مصطلحات موضوعية: | Viral diseases, HIV-1, AIDS, Disease transmission, vertical, Mother-to-child, Subtypes, Nigeria, Africa, West |
| الوصف: | The rate of mother-to-child transmission (MTCT) of HIV as well as the implications of the circulating multiple subtypes to MTCT in Nigeria are not known. This study was therefore undertaken to determine the differential rates of MTCT of HIV-1 subtypes detected among infected pregnant women before ARV intervention therapy became available in Nigeria. Twenty of the HIV-positive women who signed the informed consent form during pregnancy brought their babies for follow-up testing at age 18-24 months. Plasma samples from both mother and baby were tested for HIV antibody at the Department of Virology, UCH, Ibadan, Nigeria. All positive samples (plasma and peripheral blood mononuclear cells-PBMCs) were shipped to the Institute of Tropical Medicine, Antwerp, Belgium, where the subtype of the infecting virus was determined using the HMA technique. Overall, a mother-to-child HIV transmission rate of 45% was found in this cohort. Specifically, 36.4%, 66.7% and 100% of the women infected with HIV-1 CRF02 (IbNg), G and B, respectively, transmitted the virus to their babies. As far as it can be ascertained, this is the first report on the rate of MTCT of HIV in Nigeria. The findings reported in this paper will form a useful reference for assessment of currently available therapeutic intervention of MTCT in the country. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0036-4665 |
| العلاقة: | ITG-M3A; ITG-M4B; ITG-M5B; ITG-MLA; MICRO; U-VIROL; FTA; ABSTRACT; http://hdl.handle.net/10390/1888Test; http://www.ncbi.nlm.nih.gov/pubmed/16699628Test; http://193.190.39.98/bitstream/10390/1888/1/2006rimt0077.pdfTest |
| الإتاحة: | http://hdl.handle.net/10390/1888Test http://www.ncbi.nlm.nih.gov/pubmed/16699628Test http://193.190.39.98/bitstream/10390/1888/1/2006rimt0077.pdfTest |
| رقم الانضمام: | edsbas.975D98BF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00364665 |
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