دورية أكاديمية
Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy.
| العنوان: | Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy. |
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| المؤلفون: | Quenot, Jean-Pierre, Luyt, Charles-Edouard, Roche, Nicolas, Chalumeau, Martin, Charles, Pierre-Emmanuel, Claessens, Yann-Eric, Lasocki, Sigismond, Bedos, Jean-Pierre, Péan, Yves, Philippart, François, Ruiz, Stéphanie, Gras-Leguen, Christele, Dupuy, Anne-Marie, Pugin, Jérôme, Stahl, Jean-Paul, Misset, Benoit, Gauzit, Rémy, Brun-Buisson, Christian |
| المساهمون: | Service de Réanimation Médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Pneumologie et Soins Intensifs Respiratoires, Université Paris Descartes - Paris 5 (UPD5)-Hôpitaux Universitaires Paris Centre, Service de Pédiatrie Générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Agroécologie Dijon, Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Département d'Urgences Médicales, Centre Hospitalier Princesse Grace, Pôle d'Anesthésie Réanimation, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier de Versailles André Mignot (CHV), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Microbiologie, Institut Mutualiste de Montsouris (IMM), Service de réanimation polyvalente, GH Saint-Joseph, Pôle Anesthésie Réanimation CHU de Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Clinique Médicale et Service d'Urgences Pédiatriques, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de Biochimie, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Lapeyronie, Intensive Care - SIRS Unit, Geneva University Hospital (HUG), Service de maladies infectieuses et tropicales, Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Centre de Recherche Clinique, Université Paris Descartes - Paris 5 (UPD5)-GH Saint-Joseph, Unité de Réanimation, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) |
| المصدر: | ISSN: 2110-5820 ; Annals of Intensive Care ; https://inserm.hal.science/inserm-00845823Test ; Annals of Intensive Care, 2013, 3 (1), pp.21. ⟨10.1186/2110-5820-3-21⟩. |
| بيانات النشر: | HAL CCSD SpringerOpen |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Meningitis, Pneumonia, Emergency medicine, C-reactive protein, Pancreatitis, Biomarkers, Procalcitonin, Sepsis, Infection, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SHS.INFO]Humanities and Social Sciences/Library and information sciences |
| الوصف: | EA MERS ; International audience ; Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU. In pancreatitis with suspected infected necrosis, initiating antibiotics best relies on fine-needle aspiration and demonstration of infected material. We suggest that PCT be measured to help predict infection; however, available data are insufficient to decide on initiating antibiotics based on PCT levels. In adult patients suspected of community-acquired LRTI, we suggest withholding antibiotic therapy when the serum PCT level is low (<0.25 ng/mL); in patients having nosocomial LRTI, data are insufficient to recommend initiating therapy based on a single PCT level or even repeated measurements. For children with suspected bacterial meningitis, we recommend using a decision rule as an aid to therapeutic decisions, such as the Bacterial Meningitis Score or the Meningitest(R); a single PCT level >=0.5 ng/mL also may be used, but false-negatives may occur. In adults with suspected bacterial meningitis, we suggest integrating serum PCT measurements in a clinical decision rule to help distinguish between viral and bacterial meningitis, using a 0.5 ng/mL threshold. For ICU patients suspected of community-acquired infection, we do not recommend using a threshold serum PCT value to help the decision to initiate antibiotic therapy; data are insufficient to recommend using PCT serum kinetics for the decision to initiate antibiotic therapy in patients suspected of ICU-acquired infection. In children, CRP can probably be used to help discontinue therapy, although the evidence is limited. In adults, antibiotic discontinuation can be based on an algorithm using repeated PCT measurements. In non-immunocompromised out- or in- patients treated for RTI, antibiotics can be discontinued if the PCT level at day 3 is < 0.25 ng/mL or has decreased by >80-90%, whether or not microbiological documentation has ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23830525; inserm-00845823; https://inserm.hal.science/inserm-00845823Test; https://inserm.hal.science/inserm-00845823/documentTest; https://inserm.hal.science/inserm-00845823/file/2110-5820-3-21.pdfTest; PRODINRA: 226866; PUBMED: 23830525; WOS: 000345070200001 |
| DOI: | 10.1186/2110-5820-3-21 |
| الإتاحة: | https://doi.org/10.1186/2110-5820-3-21Test https://inserm.hal.science/inserm-00845823Test https://inserm.hal.science/inserm-00845823/documentTest https://inserm.hal.science/inserm-00845823/file/2110-5820-3-21.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.96BD1400 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/2110-5820-3-21 |
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