دورية أكاديمية
Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation-study on behalf of CMWP of the EBMT.
| العنوان: | Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation-study on behalf of CMWP of the EBMT. |
|---|---|
| المؤلفون: | Drozd-Sokołowska, J., Gras, L., Zinger, N., Snowden, J. A., Arat, M., Basak, G., Pouli, A., Crawley, C., Wilson, K. M. O., Tilly, Hervé, Byrne, J., Bulabois, Claude E., Passweg, J., Ozkurt, Z. N., Schroyens, W., Lioure, Bruno, Colorado Araujo, M., Poiré, X., Van Gorkom, G., Gurman, G., De Wreede, L. C., Hayden, P. J., Beksac, M., Schönland, S. O., Yakoub-Agha, Ibrahim |
| المساهمون: | Université de Lille, Inserm, CHU Lille, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen CLCC Henri Becquerel, Université Grenoble Alpes UGA, Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286 |
| سنة النشر: | 2024 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| الوصف: | Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse. ; 57 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf |
| اللغة: | English |
| العلاقة: | Bone Marrow Transplantation; Bone Marrow Transplant; http://hdl.handle.net/20.500.12210/100892Test |
| الإتاحة: | https://doi.org/20.500.12210/100892Test https://hdl.handle.net/20.500.12210/100892Test |
| حقوق: | Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.958BA1BA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |