التفاصيل البيبلوغرافية
| العنوان: |
Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity |
| المؤلفون: |
Slusher, Aaron L., Nouws, Jessica, Tokoglu, Fuyuze, Vash‐Margita, Alla, Matthews, Marcy D., Fitch, Mark, Shankaran, Mahalakshmi, Hellerstein, Marc K., Caprio, Sonia |
| المساهمون: |
Foundation for the National Institutes of Health, Robert E. Leet and Clara Guthrie Patterson Trust |
| المصدر: |
Obesity ; volume 32, issue 3, page 593-602 ; ISSN 1930-7381 1930-739X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Objective The objective of this study was to examine the hypothesis that abdominal and gluteal adipocyte turnover, lipid dynamics, and fibrogenesis are dysregulated among insulin‐resistant (IR) compared with insulin‐sensitive (IS) adolescents with obesity. Methods Seven IS and seven IR adolescents with obesity participated in a 3‐h oral glucose tolerance test and a multi‐section magnetic resonance imaging scan of the abdominal region to examine body fat distribution patterns and liver fat content. An 8‐week 70% deuterated water ( 2 H 2 O) labeling protocol examined adipocyte turnover, lipid dynamics, and fibrogenesis in vivo from biopsied abdominal and gluteal fat. Results Abdominal and gluteal subcutaneous adipose tissue (SAT) turnover rates of lipid components were similar among IS and IR adolescents with obesity. However, the insoluble collagen (type I, subunit α2) isoform measured from abdominal, but not gluteal, SAT was elevated in IR compared with IS individuals. In addition, abdominal insoluble collagen Iα2 was associated with ratios of visceral‐to‐total (visceral adipose tissue + SAT) abdominal fat and whole‐body and adipose tissue insulin signaling, and it trended toward a positive association with liver fat content. Conclusions Altered extracellular matrix dynamics, but not expandability, potentially decreases abdominal SAT lipid storage capacity, contributing to the pathophysiological pathways linking adipose tissue and whole‐body IR with altered ectopic storage of lipids within the liver among IR adolescents with obesity. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/oby.23974 |
| الإتاحة: |
https://doi.org/10.1002/oby.23974Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.957383BF |
| قاعدة البيانات: |
BASE |
