دورية أكاديمية
Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients
| العنوان: | Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients |
|---|---|
| المؤلفون: | Topol, A, English, JA, Flaherty, E, Rajarajan, P, Hartley, BJ, Gupta, S, Desland, F, Zhu, S, Goff, T, Friedman, L, Rapoport, J, Felsenfeld, D, Cagney, G, Mackay-Sim, A, Savas, JN, Aronow, B, Fang, G, Zhang, B, Cotter, D, Brennand, KJ |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2015 |
| المجموعة: | Griffith University: Griffith Research Online |
| مصطلحات موضوعية: | Clinical sciences, Medical genetics (excl. cancer genetics) |
| الوصف: | The genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly increased levels of ribosomal and translation initiation and elongation factor proteins, in SZ hiPSC NPCs. We posit that perturbed levels of global protein synthesis in SZ hiPSC NPCs represent a novel post-transcriptional mechanism that might contribute to disease progression. ; Full Text |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2158-3188 |
| العلاقة: | Translational Psychiatry; http://hdl.handle.net/10072/123421Test |
| DOI: | 10.1038/tp.2015.118 |
| الإتاحة: | https://doi.org/10.1038/tp.2015.118Test http://hdl.handle.net/10072/123421Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; © The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.95373ECF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21583188 |
|---|---|
| DOI: | 10.1038/tp.2015.118 |