دورية أكاديمية
Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma
| العنوان: | Whole blood EBV-DNA predicts outcome in diffuse large B-cell lymphoma |
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| المؤلفون: | Tisi, MC, Cupelli, E, Santangelo, R, Maiolo, E, Alma, E, Giachelia, M, Martini, M, Bellesi, S, D'Alò, F, Pompili, M, Leone, G, Larocca, Lm, Hohaus, S., VOSO, MARIA TERESA |
| المساهمون: | Tisi, M, Cupelli, E, Santangelo, R, Maiolo, E, Alma, E, Giachelia, M, Martini, M, Bellesi, S, D'Alò, F, Voso, Mt, Pompili, M, Leone, G, Larocca, L, Hohaus, S |
| سنة النشر: | 2015 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Diffuse large B-cell lymphoma, EBV, prognosis, Settore MED/15 - MALATTIE DEL SANGUE |
| الوصف: | An association between Epstein-Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In a cohort of 218 human immunodeficiency virus (HIV)-negative patients with diffuse large B-cell lymphomas, we detected EBV-DNA in 25% of whole blood (WB) samples at diagnosis. Presence and viral load in WB, mononuclear cells or plasma did not predict the presence of EBV in the tumor biopsy. Positive Hepatitis C virus (HCV) serology was associated with a higher frequency of EBV in WB. Patients with EBV-DNA in WB had a significantly shorter progression-free (p = 0.02) and overall survival (p = 0.05) after immunochemotherapy with R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone). We conclude that detection of EBV in WB is not a surrogate marker for EBV-association in diffuse large B-cell lymphoma, however it associates with worse outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26458141; info:eu-repo/semantics/altIdentifier/wos/WOS:000372499800020; volume:57; issue:3; firstpage:628; lastpage:634; numberofpages:7; journal:LEUKEMIA & LYMPHOMA; http://hdl.handle.net/2108/134515Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84945237066 |
| DOI: | 10.3109/10428194.2015.1072766 |
| الإتاحة: | https://doi.org/10.3109/10428194.2015.1072766Test http://hdl.handle.net/2108/134515Test |
| رقم الانضمام: | edsbas.951B78B3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3109/10428194.2015.1072766 |
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