دورية أكاديمية
Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations:The OPTIPARK open-label study
| العنوان: | Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations:The OPTIPARK open-label study |
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| المؤلفون: | Reichmann, Heinz, Lees, Andrew, Rocha, José Francisco, Magalhães, Diogo, Soares-Da-Silva, Patrício, Zolnai, Csaba Antal, Bartels, Claudius, Barth, Andreas, Barth, Kriemhild, Behrens, Stephan, Bergmann, Arnfin, Bodenschatz, Ralf, Born, Rommy, Brandt, Moriz, Brock, Sebastian, Brockmeier, Bernd, Brücke, Christof, Brüggemann, Norbert, Bühler, Bernhard, Bungard, Uwe, Cepek, Lukas, Csoti, Ilona, Deist, Max, Reimers, Carl Detlev, Dölle, Ulrich, Domke, Sylke, Dzialowski, Imanuel, Ebersbach, Georg, Eggert, Heike, Eggert, Karla, Ehret, Reinhard, Engel, Jana, Fietzek, Urban, Friedrich, Anke, Fritzinger, Michael, Gandor, Florin, Gehring, Klaus, Gierer, Stephan, Gierer, Stephanie, Gjaurov, Vasil, Gruber, Doreen, Günes, Özkan, Haas, Thomas, Hahn, Kirsten, Haraszti, Anna Eszter, Hartmann, Rolf, Haslinger, Bernhard, Heiss, Eva, Herbst, Heinz P., Hoffmann, Frank, Hofmann, Werner E., Höglinger, Günter, Jost, Wolfgang, Kavcic, Anna Maria, Kellinghaus, Christoph, Klemperer, Bertold, Klostermann, Fabian, Knoll, Thomas, Koleva-Alazeh, Natalia, Koschel, Jiri, Kraft-Safavi, Diana Waltraud, Kronenberger, Almut, Kühn, Andrea, Kupsch, Andreas, Lehnhoff, Thomas, Laumen, Peter, Lingor, Paul, Lippmann, Karla, Lorrain, Michael, Maass, Fabian, Muhlack, Siegfried, Müller, Thomas, Nagel, Michael, Neudecker, Stephan, Odin, Katja, Oehlwein, Christian, Orbasli, Hakan, Von Pannwitz, Wolfram, Pape, Heidi, Pfister, Robert, Prell, Tino, Puzich, Reinhard, Rau, Daniela, Reese, Rene, Reifschneider, Gerd, Reimann, Gernot, Ries, Stefani, Rieth, Christoph, Rewitzer, Charlotte, Safavi, Ali, Schmied, Alexander B., Schwarz, Johannes, Schwarz, Wolfgang, Springub, Joachim, Claus, Inga Suttrup, Tadic, Vera, Tiel-Wilck, Klaus, Tönges, Lars, Tröger, Jens, Schrey, Christoph, Schulze, Alexander, Thonke, Sven, Wächter, Tobias, Wannenmacher, Achim S., Warnecke, Tobias, Wieder, Bettina, Wimmer, Martin, Winkler, Christian, Witte, Otto, Woitalla, Dirk, Zella, Samis, Ziebold, Uwe, Alty, Jane, Amin, Reem, Boca, Michaela, Butterworth, Stephen, Carroll, Camille, Charlesworth, Gavin, Chaudhuri, K. Ray, Chinnadurai, Rajkumar, Collins, Jemima, Cosgrove, Jeremy Stephen, Cravey, Samantha, Damodaran, Dinesh, Dimitrov, Nikolay, Durcan, Rory, Ellis, Simon, Elmarimi, Adbdul, Evans, Jonathan, Fisher, James, Grosset, Donald, Jamieson, Stuart, Kobylecki, Christopher, Lim, Sze Hway, Lyell, Veronica, Mohamed, Biju, Molloy, Sophie, Pavese, Nicola, Paviour, Dominic, Purchas, Madeleine, Rashed, Khalid, Rickards, Christopher, Saifee, Tabish, Sare, Gillian, Schofield, Christine, Setty, Naveen, Sharma, Jagdish, Sheridan, Ray, Shu, Siew Lee, Silverdale, Monty, Sophia, Rani, Statton, Sarah, Steiger, Malcolm, Thomas, Christopher, Walker, Richard, Foung, Tai Yen |
| المصدر: | Reichmann , H , Lees , A , Rocha , J F , Magalhães , D , Soares-Da-Silva , P , Zolnai , C A , Bartels , C , Barth , A , Barth , K , Behrens , S , Bergmann , A , Bodenschatz , R , Born , R , Brandt , M , Brock , S , Brockmeier , B , Brücke , C , Brüggemann , N , Bühler , B , Bungard , U , Cepek , L , Csoti , I , Deist , M , Reimers , C D , .... |
| سنة النشر: | 2020 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Levodopa, Motor fluctuations, Open-label, Opicapone, Parkinson's disease |
| الوصف: | Background: The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. Methods: OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson's disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months in addition to their current levodopa and other antiparkinsonian treatments. The primary endpoint was the Clinician's Global Impression of Change (CGI-C) after 3 months. Secondary assessments included Patient Global Impressions of Change (PGI-C), the Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ-8), and the Non-Motor Symptoms Scale (NMSS). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). Results: Of the 506 patients enrolled, 495 (97.8%) took at least one dose of opicapone. Of these, 393 (79.4%) patients completed 3 months of treatment. Overall, 71.3 and 76.9% of patients experienced any improvement on CGI-C and PGI-C after 3 months, respectively (full analysis set). At 6 months, for UK subgroup only (n = 95), 85.3% of patients were judged by investigators as improved since commencing treatment. UPDRS scores at 3 months showed statistically significant improvements in activities of daily living during OFF (mean ± SD change from baseline: - 3.0 ± 4.6, p < 0.0001) and motor scores during ON (- 4.6 ± 8.1, p < 0.0001). The mean ± SD improvements of - 3.4 ± 12.8 points for PDQ-8 and -6.8 ± 19.7 points for NMSS were statistically significant versus baseline (both p < 0.0001). Most of TEAEs (94.8% of events) were of mild or moderate intensity. TEAEs considered to be at least possibly related to opicapone were reported for 45.1% of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s40035-020-00187-1 |
| الإتاحة: | https://doi.org/10.1186/s40035-020-00187-1Test https://kclpure.kcl.ac.uk/portal/en/publications/51fb0dad-a5ea-43da-8dbb-dbeb069672ceTest http://www.scopus.com/inward/record.url?scp=85081229949&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9506D003 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40035-020-00187-1 |
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