دورية أكاديمية
Foot Ulcer and Risk of Lower Limb Amputation or Death in People With Diabetes:A National Population-Based Retrospective Cohort Study
| العنوان: | Foot Ulcer and Risk of Lower Limb Amputation or Death in People With Diabetes:A National Population-Based Retrospective Cohort Study |
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| المؤلفون: | Chamberlain, Rosemary C., Fleetwood, Kelly, Wild, Sarah H., Colhoun, Helen M., Lindsay, Robert S., Petrie, John R., McCrimmon, Rory J., Gibb, Fraser, Philip, Sam, Sattar, Naveed, Kennon, Brian, Leese, Graham P. |
| المصدر: | Chamberlain , R C , Fleetwood , K , Wild , S H , Colhoun , H M , Lindsay , R S , Petrie , J R , McCrimmon , R J , Gibb , F , Philip , S , Sattar , N , Kennon , B & Leese , G P 2022 , ' Foot Ulcer and Risk of Lower Limb Amputation or Death in People With Diabetes : A National Population-Based Retrospective Cohort Study ' , Diabetes Care , vol. 45 , no. 1 , pp. 83-91 . https://doi.org/10.2337/dc21-1596Test |
| سنة النشر: | 2022 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | /dk/atira/pure/subjectarea/asjc/2900/2902, name=Advanced and Specialised Nursing, /dk/atira/pure/subjectarea/asjc/2700/2724, name=Internal Medicine, /dk/atira/pure/subjectarea/asjc/2700/2712, name=Endocrinology, Diabetes and Metabolism |
| الوصف: | Objective : To describe incidence of foot ulceration and amputation-free survival associated with foot ulceration status in a national population-based cohort study of people with diabetes. Research Design and Methods : The study population included 233,459 people with diabetes who were alive in Scotland on 1 January 2012 identified from the national population-based register (national prevalence 4.9%). Characteristics of patients identified from linked hospital and mortality records during follow-up to the end of November 2017 were compared by outcome. Cox regression was used to assess the association between history of foot ulcer and amputation-free survival. Results : The population included 23,395 people with type 1 diabetes and 210,064 people with type 2 diabetes. In total there were 13,093 (5.6%) people who had a previous foot ulceration, 9,023 people who developed a first ulcer, 48,995 who died, and 2,866 who underwent minor or major amputation during follow-up. Overall incidence of first-time foot ulcers was 7.8 per 1,000 person-years (95% CI7.6-7.9) and 11.2 (11.0-11.4) for any ulcer. Risk factors for reduced amputation-free survival included social deprivation, mental illness, and being underweight in addition to conventional cardiovascular risk factors. Adjusted hazard ratios (95% CI) were 2.09 (1.89-2.31) for type 1 diabetes and 1.65 (1.60-1.70) for type 2 diabetes. Conclusions : The overall incidence of foot ulceration in a population-based study of people with diabetes was 11.2 per 1,000 person-years. Foot ulceration is associated with lower amputation-free survival rate, a potential measure of effectiveness of care among people with diabetes. Mental illness and social deprivation are also highlighted as risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/6c6c1ac1-5ae1-4efd-8710-29934703f537Test |
| DOI: | 10.2337/dc21-1596 |
| الإتاحة: | https://doi.org/10.2337/dc21-1596Test https://discovery.dundee.ac.uk/en/publications/6c6c1ac1-5ae1-4efd-8710-29934703f537Test https://discovery.dundee.ac.uk/ws/files/70133407/259399.pdfTest http://www.scopus.com/inward/record.url?scp=85123287404&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9506CB08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/dc21-1596 |
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