دورية أكاديمية
The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study
| العنوان: | The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study |
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| المؤلفون: | Fest, J. (Jesse), Ruiter, T.R. (Rikje), Groot Koerkamp, B. (Bas), Rizopoulos, D. (Dimitris), Ikram, M.A. (Arfan), Eijck, C.H.J. (Casper) van, Stricker, B.H.Ch. (Bruno) |
| المصدر: | European Journal of Epidemiology |
| سنة النشر: | 2018 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Low-grade inflammation, Mortality, Neutrophil-to-lymphocyte ratio |
| الوصف: | Inflammation is a risk factor for morbidity and mortality in the elderly. The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that integrates the information of the leukocyte differentials into one variable. We aimed to assess whether the NLR is a risk indicator for overall and cause-specific mortality in the general population. We analyzed data (2002–2014) from the Rotterdam Study, a long-standing, population-based, prospective cohort study in a community-dwelling ageing population. The association between the NLR and time to all-cause mortality was assessed with Cox proportional hazard models. We additionally assessed cardiovascular, cancer and other mortality. The multivariable analyses were adjusted for age, gender, socio-economic status (SES), smoking status, body mass index, type 2 diabetes, and history of cancer and cardiovascular disease (CVD). Data of 8715 individuals were included. The mean age was 65.9 years (SD 10.5) and the majority were women (57.1%). The NLR was higher in men, higher age categories, smokers and among individuals with lower SES, prevalent diabetes, or a history of cancer or CVD. During the 11.7 years follow-up period, 1641 individuals |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/113453Test; urn:hdl:1765/113453 |
| DOI: | 10.1007/s10654-018-0472-y |
| الإتاحة: | https://doi.org/10.1007/s10654-018-0472-yTest http://repub.eur.nl/pub/113453Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.94C92078 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10654-018-0472-y |
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