دورية أكاديمية

Comparison of the in vitro effects of amoxicillin and ampicillin on the polymorphonuclear neutrophil respiratory burst

التفاصيل البيبلوغرافية
العنوان: Comparison of the in vitro effects of amoxicillin and ampicillin on the polymorphonuclear neutrophil respiratory burst
المؤلفون: Reynaert, Marie-Line, Hochart-Behra, Anne-Cécile, Behra-Miellet, Josette, Gressier, Bernard, Mine, Louis, Dine, Thierry, Luyckx, Michel, Dubreuil, Luc, Brunet, Claude
بيانات النشر: Oxford University Press
سنة النشر: 2009
المجموعة: HighWire Press (Stanford University)
مصطلحات موضوعية: Original research
الوصف: Objectives The aim was to compare the in vitro effects of amoxicillin and ampicillin on the oxidative metabolism of polymorphonuclear neutrophils (PMNs). Methods Superoxide radical anion production by PMNs, stimulated or not by various exogenous stimulants and in contact with increasing antibiotic concentrations, was measured using spectrophotometric methods. Results Whereas a pro-oxidative action of amoxicillin on PMNs was obtained without exogenous stimulation or with opsonized zymosan (OZ), the O 2 − production by PMNs incubated with ampicillin did not increase significantly. Conclusions This amoxicillin pro-oxidative effect could be due to the activation of the PMN NADPH oxidase, to its induction by a membrane effect or via the OZ pathway. It probably reinforces amoxicillin intrinsic bactericidal action and might partly explain the severe rashes sometimes occurring with amoxicillin treatment.
نوع الوثيقة: text
وصف الملف: text/html
اللغة: English
العلاقة: http://jac.oxfordjournals.org/cgi/content/short/dkn545v1Test; http://dx.doi.org/10.1093/jac/dkn545Test
DOI: 10.1093/jac/dkn545
الإتاحة: https://doi.org/10.1093/jac/dkn545Test
http://jac.oxfordjournals.org/cgi/content/short/dkn545v1Test
حقوق: Copyright (C) 2009, The British Society for Antimicrobial Chemotherapy
رقم الانضمام: edsbas.94BBFE86
قاعدة البيانات: BASE