دورية أكاديمية
Pandemic chilblains: Are they SARS-CoV-2-related or not?
| العنوان: | Pandemic chilblains: Are they SARS-CoV-2-related or not? |
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| المؤلفون: | De Greef, Axel, Coulie, Pierre G., Baeck, Marie |
| المساهمون: | UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin), UCL - (SLuc) Service de dermatologie, UCL - (SLuc) Centre de l'allergie |
| المصدر: | Clinical immunology, Vol. 237, p. 108984 [1-3] (2022) |
| بيانات النشر: | Academic Press |
| سنة النشر: | 2022 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | COVID-19, Chilblains, Humans, Pandemics, SARS-CoV-2, Skin, Cold, Pandemic, Trigger, Type 1 interferon |
| الوصف: | The exact etiopathology of chilblains observed during the Coronavirus Disease 2019 (COVID-19) pandemic is still unclear. Initially, SARS-CoV-2 appeared as the obvious causing agent, but two years of various investigations have failed to convincingly support its direct implication. Most affected individuals have no detectable virus, no anti-SARS-CoV-2 antibodies and no symptoms of COVID-19. Analyses of skin biopsies similarly failed to unambiguously demonstrate presence of the virus or its genome. In a recent hypothesis, SARS-CoV-2 would cause the lesions before being promptly eliminated by unusually strong type I interferon responses. With others, we feel that environmental factors have not been sufficiently considered, in particular cold exposure related to unprecedented containment measures. The cause of pandemic chilblains remains a stimulating puzzle which warrants further investigation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1521-6616 1521-7035 |
| العلاقة: | boreal:262806; http://hdl.handle.net/2078.1/262806Test; info:pmid/35338000; urn:ISSN:1521-6616; urn:EISSN:1521-7035 |
| DOI: | 10.1016/j.clim.2022.108984 |
| الإتاحة: | https://doi.org/10.1016/j.clim.2022.108984Test http://hdl.handle.net/2078.1/262806Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9492DA5 |
| قاعدة البيانات: | BASE |
| تدمد: | 15216616 15217035 |
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| DOI: | 10.1016/j.clim.2022.108984 |