دورية أكاديمية
hPG 80 (Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine Tumors
| العنوان: | hPG 80 (Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine Tumors |
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| المؤلفون: | Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Léa Payen, Younes Mahi, Berengere Vire, Madison Sands, B. Mark Evers, Dominique Joubert, Lowell Anthony |
| المصدر: | Cancers, Vol 14, Iss 863, p 863 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | circulating progastrin, hPG 80, blood-based diagnostic biomarker, neuroendocrine neoplasms, neuroendocrine tumors, neuroendocrine carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Current blood-based biomarkers for neuroendocrine neoplasms (NENs) lack both sensitivity and specificity. Human circulating progastrin (hPG 80 ) is a novel biomarker that can be easily measured in plasma by ELISA. This study is the first to examine hPG 80 in NENs. Plasma hPG 80 was quantified from 95 stage IV NEN patients, using DxPG 80 technology (ECS Progastrin, Switzerland) and compared with hPG 80 concentrations in two cohorts of healthy donor controls aged 50–80 ( n = 252) and 18–25 ( n = 137). Median hPG 80 in NENs patients was 5.54 pM compared to 1.5 pM for the 50–80 controls and 0.29 pM the 18–25 cohort ( p < 0.0001). Subgroup analysis revealed median hPG 80 levels significantly higher than for either control cohort in neuroendocrine carcinoma (NEC; n = 25) and neuroendocrine tumors (NET; n = 70) including the small-cell lung cancer (SCLC) sub-cohort ( n = 13). Diagnostic accuracy, estimated by AUCs, was high for NENs, as well as both sub-groups (NEC/NET) when compared to the younger and older control groups. Plasma hPG 80 in NENs may be a diagnostic blood biomarker for both low- and high-grade NENs; further study is warranted. A prospective multi-center trial is ongoing in NET to evaluate hPG 80 as a means of monitoring disease (NCT04750954). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/14/4/863Test; https://doaj.org/toc/2072-6694Test; https://doaj.org/article/6dd6721d72fb4668b39b3e4c67adbcf9Test |
| DOI: | 10.3390/cancers14040863 |
| الإتاحة: | https://doi.org/10.3390/cancers14040863Test https://doaj.org/article/6dd6721d72fb4668b39b3e4c67adbcf9Test |
| رقم الانضمام: | edsbas.943E1B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers14040863 |