دورية أكاديمية
Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood
| العنوان: | Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood |
|---|---|
| المؤلفون: | Roeper, Marcia, Hoermann, Henrike, Körner, Lisa M., Sobottka, Marvin, Mayatepek, Ertan, Kummer, Sebastian, Meissner, Thomas |
| المصدر: | JAMA Network Open ; volume 7, issue 3, page e243683 ; ISSN 2574-3805 |
| بيانات النشر: | American Medical Association (AMA) |
| سنة النشر: | 2024 |
| الوصف: | Importance The circumstances under which neonatal hypoglycemia leads to brain damage remain unclear due to a lack of long-term data on the neurodevelopment of affected children. As a result, diagnostic strategies and treatment recommendations are inconsistent. Objective To evaluate whether the occurrence of severe transitional neonatal hypoglycemia (defined as having at least 1 blood glucose measurement of 30 mg/dL or below) is associated with adverse neurodevelopment in midchildhood. Design, Setting, and Participants This cohort study using neurodevelopmental testing of a retrospectively recruited cohort was conducted at a single-center tertiary hospital in Germany between March 2022 and February 2023. Children with neonatal blood glucose screening data were randomly selected from all births between 2010 and 2015. Frequency matching for sex, birth weight, gestational age, socioeconomic status, and primary risk factors for neonatal hypoglycemia was performed. Children with persistent hypoglycemia diseases or any risk factor for adverse neurodevelopment except hypoglycemia were excluded. Data were analyzed between February 2023 and March 2023. Exposure At least 1 neonatal hypoglycemia measurement with blood glucose measuring 30 mg/dL or below vs all measured blood glucose levels above 30 mg/dL during postnatal blood glucose screening starting on the first day of life. Main Outcomes and Measures Cognitive function measured by full-scale IQ test. Secondary outcomes included standardized scales of motor, visual, and executive functions, and child behavior, each measured at ages 7 to 11 years. Results A total of 140 children (mean [SD] age 9.1 [1.3] years; 77 male [55.0%]) participated in the study. Children with severe neonatal hypoglycemia had a 4.8 points lower mean full-scale IQ than controls (107.0 [95% CI, 104.0-109.9] vs 111.8 [95% CI, 108.8-114.8]). They showed a 4.9-fold (95% CI, 1.5-15.5) increased odds of abnormal fine motor function and a 5.3-fold (95% CI, 2.1-13.3) increased odds of abnormal visual-motor ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1001/jamanetworkopen.2024.3683 |
| الإتاحة: | https://doi.org/10.1001/jamanetworkopen.2024.3683Test https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2816746/roeper_2024_oi_240158_1710778720.81828.pdfTest |
| رقم الانضمام: | edsbas.93DB5CCF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamanetworkopen.2024.3683 |
|---|