دورية أكاديمية
Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study
| العنوان: | Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study |
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| المؤلفون: | Schutte, R., Huisman, H.W, Malan, L., Van Rooyen, J.M., Smith, W. |
| المساهمون: | 12201405 - Schutte, Rudolph, 10062718 - Huisman, Hugo Willem, 10060871 - Malan, Leoné, 10059539 - Van Rooyen, Johannes Marthinus, 22945717 - Smith, Wayne |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | North-West University, South Africa: Boloka (NWU-IR) |
| مصطلحات موضوعية: | Serum alkaline phosphatase, ambulatory blood pressure, carotid intima–media thickness, hypertensive African men |
| الوصف: | Background: Vascular calcification is believed to be due to the conversion of vascular smooth muscle cells into osteoblast-like cells and is associated with mortality. Since hypertension and related mortality in Africans is a concern, we investigated associations between a marker of osteoblastic activity, alkaline phosphatase (ALP), and measures of arterial structure and function in hypertensive African men. Methods: This study included 79 participants. We conducted 24 h ambulatory blood pressure and carotid intima–media thickness (cIMT) measurements. cIMT was obtained with an intra-observer variability of 0.04 mm and the cross-sectional wall area (CSWA) was calculated. ALP was measured in serum. Results: ALP was within its reference range (101.6 vs. 30.0–120.0 U/L), however cIMT was higher when this group was stratified and compared to gender and age-specific reference values. In univariate and partial regressions, and confirmed with multiple regression analyses, 24 h systolic blood pressure (β=0.289, p=0.018), 24 h pulse pressure (β=0.387, p=0.002), but not 24 h diastolic blood pressure (β=0.073, p=0.58), were positively associated with ALP. In addition, mean cIMT (β=0.322, p=0.006) and CSWA (β=0.285, p=0.013) also correlated positively with ALP after adjusting for significant covariates, and after excluding participants with diabetes, renal dysfunction or a HIV positive status. Conclusion: Serum alkaline phosphatase is adversely associated with measures of arterial structure and function in hypertensive African men. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-16-752731-2 0-16-752731-2 |
| تدمد: | 0167-5273 |
| العلاقة: | Schutte, R. et al. 2013. Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study. International journal of cardiology. 167:1995-2001. [http://www.journals.elsevier.com/international-journal-of-cardiologyTest/]; 1874-1754 (Online); http://hdl.handle.net/10394/14060Test; http://www.journals.elsevier.com/international-journal-of-cardiologyTest/; https://pubmed.ncbi.nlm.nih.gov/22656046Test/; https://www.sciencedirect.com/science/article/abs/pii/S0167527312006468Test |
| الإتاحة: | http://hdl.handle.net/10394/14060Test http://www.journals.elsevier.com/international-journal-of-cardiologyTest/ https://pubmed.ncbi.nlm.nih.gov/22656046Test/ https://www.sciencedirect.com/science/article/abs/pii/S0167527312006468Test |
| رقم الانضمام: | edsbas.93D99FB5 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780167527312 0167527312 |
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| تدمد: | 01675273 |